Apolipoprotein A, Apo A Native Protein | Apo A native protein

Apolipoprotein A, Apo A (60-70% purity)

Cat. Num. AAA355782

• Gene Names: LPA; LP; AK38; APOA
• Applications: ELISA
• Purity: 60-70% by SDS-PAGE
• Synonyms: Apolipoprotein A; Apo A; Apo A (60-70% purity); Apolipoprotein A Protein; Purified human Apolipoprotein A protein; Apo A native protein

• Host: Human serum
• Purity/Purification: 60-70% by SDS-PAGE
• Form/Format: Liquid; Each vial contains 10mM PBS (pH 7.4)
• Sequence Length: 2040

• Applicable Applications for Apo A native protein: ELISA
• Preparation and Storage: Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.; Avoid repeated freeze and thaw cycles.

Related Product Information for Apo A native protein

Background: Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems. They transport the lipids through the lymphatic and circulatory systems. Apoprotein A is one of exchangeable apolipoproteins which have the same genomic structure and are members of a multi-gene family that probably evolved from a common ancestral gene. ApoA1 and ApoA4 are part of the APOA1/C3/A4/A5 gene cluster on chromosome 11. They are consist of alpha-helices and associate with lipid droplets reversibly.

References

Saito H, Lund-Katz S, Phillips MC (July 2004). "Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins". Prog. Lipid Res. 43 (4): 350-80. Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA; Wardell; Weisgraber; Mahley; Agard (June 1991). "Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E". Science 252 (5014): 1817-22.

NCBI and Uniprot Product Information

• NCBI GI #: 116292750
• NCBI GeneID: 4018
• NCBI GenBank Nucleotide #: NM_005577.2
• NCBI Official Full Name: apolipoprotein(a)
• NCBI Official Synonym Full Names: lipoprotein(a)
• NCBI Official Symbol: LPA
• NCBI Official Synonym Symbols: LP; AK38; APOA
• NCBI Protein Information: apolipoprotein(a)
• UniProt Protein Name: Apolipoprotein(a)
• UniProt Gene Name: LPA
• UniProt Synonym Gene Names: Apo(a); Lp(a)
• UniProt Entry Name: APOA_HUMAN

NCBI Description

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

Uniprot Description

Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.