Mouse anti-Human CD45R Monoclonal Antibody | anti-CD45R antibody
CD45R Antibody
Reactivity
Human
Synonyms
CD45R; Monoclonal Antibody; CD45R Antibody; anti-CD45R antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Application Notes
Dilution Range: 1:100 - 1:400
Positive Control
Lymph Node, Tonsil
Immunohistochemistry (IHC)
(CD45R [IHC536] on Tonsil)
Related Product Information for anti-CD45R antibody
CD45R, also known as MB1, is an isoform of CD45 that is a member of the protein tyrosine phosphatase (PTPase) family. CD45R is expressed specifically on the surface of hematopoietic cells, and has demonstrated function as a regulator of the antigen and cytokine receptor signalling of B and T cells. Given that the antigen is located in the membrane of all B cells, with the exception of plasma cells and some mature T cells, Anti-CD45R exhibits specific reactivity with most B lymphocytes. The use of Anti-CD45R is primarily useful in distinguishing B cell lymphomas from T cell lymphomas, with specific reactivity to follicle center cells, mantle cells, some medullary thymocytes, and 80% of B cell lymphomas.
References
1. Myskow M, et al. Am J Clin Pathol. 1988; 90:564-74. 2. Shin S, et al. Hum Pathol. 1992; 23:686-94.
