Interleukin-15 (IL-15) Western Blot Control | IL-15 western blot control

Interleukin-15 (IL-15) (Western Blot Control)

Cat. Num. AAA343063

• Gene Names: IL15; IL-15
• Purity: >= 95% (SDS PAGE)
• Synonyms: Interleukin-15 (IL-15); Interleukin-15 (IL-15) (Western Blot Control); IL-15; MGC9721; Interleukin-15 (Western Blot Control); IL-15 western blot control

• Purity/Purification: >= 95% (SDS PAGE)
• Form/Format: Liquid
• Sequence Length: 135

• Buffer: Buffered 50% glycerol

Related Product Information for IL-15 western blot control

Interleukin-15 is a potent immunoregulatory cytokine produced by a variety of cell types including monocytes, epithelial cells and fibroblasts. IL-15 shares many of its biological properties with IL-2 including T, B and NK cell stimulation and has also been demonstrated to promote division of CD8 memory cells and activate IL4 production in bone marrow-derived mast cells. Recombinant Interleukin-15 comprises a 114 amino acid fragment (49-162) corresponding to the mature Interleukin-15 protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Product Categories/Family for IL-15 western blot control

Recombinant Proteins; Interleukin-15

References

Giri, J.G. (1995) J. Leukocyte Biol. 57 (5): 763-766.

NCBI and Uniprot Product Information

• NCBI GI #: 26787984
• NCBI GeneID: 3600
• NCBI Accession #: NP_751914.1
• NCBI GenBank Nucleotide #: NM_172174.2
• UniProt Accession #: P40933; O00440; O43512; Q495Z8; Q6FGX7; Q93058; Q9UBA3; D3DNZ2
• Molecular Weight: 14,912 Da
• NCBI Official Synonym Full Names: interleukin 15
• NCBI Official Symbol: IL15
• NCBI Official Synonym Symbols: IL-15
• NCBI Protein Information: interleukin-15
• UniProt Protein Name: Interleukin-15
• Protein Family: Interleukin
• UniProt Gene Name: IL15
• UniProt Synonym Gene Names: IL-15
• UniProt Entry Name: IL15_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

Uniprot Description

IL15: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cytoplasm; endosome; extracellular region; Golgi apparatus; integral to plasma membrane; membrane; nucleoplasm

Molecular Function: cytokine activity; protein binding

Biological Process: cell-cell signaling; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of tissue remodeling; signal transduction; tyrosine phosphorylation of Stat5 protein