HAO1 blocking peptide

HAO1 Peptide

Cat. Num. AAA3231366

• Gene Names: HAO1; GOX; GOX1; HAOX1
• Applications: Western Blot
• Synonyms: HAO1; HAO1 Peptide; HAO1 blocking peptide

• Form/Format: Lyophilized powder
• Sequence Length: 370

• Applicable Applications for HAO1 blocking peptide: Western Blot (WB)
• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for HAO1 blocking peptide

This is a synthetic peptide designed for use in combination with anti-HAO1 antibody made

Target Description: Subcellular location of HAO1 is the peroxisome. Specifically, HAO1 is expressed primarily in liver and pancreas and is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids.This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.

Product Categories/Family for HAO1 blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 11068137
• NCBI GeneID: 54363
• NCBI Accession #: NP_060015
• NCBI GenBank Nucleotide #: NM_017545
• UniProt Accession #: Q9UJM8
• Molecular Weight: 41kDa
• NCBI Official Full Name: hydroxyacid oxidase 1
• NCBI Official Synonym Full Names: hydroxyacid oxidase 1
• NCBI Official Symbol: HAO1
• NCBI Official Synonym Symbols: GOX; GOX1; HAOX1
• NCBI Protein Information: hydroxyacid oxidase 1
• UniProt Protein Name: Hydroxyacid oxidase 1
• Protein Family: Hydroxyacid oxidase
• UniProt Gene Name: HAO1
• UniProt Synonym Gene Names: GOX1; HAOX1; HAOX1; GOX
• UniProt Entry Name: HAOX1_HUMAN

NCBI Description

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]

Uniprot Description

HAO1: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate. Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Protein type: EC 1.1.3.15; Oxidoreductase; Carbohydrate Metabolism - glyoxylate and dicarboxylate

Chromosomal Location of Human Ortholog: 20p12

Cellular Component: peroxisomal matrix; peroxisome

Molecular Function: glycolate oxidase activity; FMN binding; glyoxylate oxidase activity; (S)-2-hydroxy-acid oxidase activity; receptor binding

Biological Process: glyoxylate metabolic process; response to oxidative stress; glycolate catabolic process; fatty acid alpha-oxidation