EIF4G2 blocking peptide

EIF4G2 Peptide - N-terminal region

Cat. Num. AAA3230139

• Gene Names: EIF4G2; P97; AAG1; DAP5; NAT1
• Applications: Western Blot
• Synonyms: EIF4G2; EIF4G2 Peptide - N-terminal region; EIF4G2 blocking peptide

• Form/Format: Lyophilized powder
• Sequence Length: 907

• Applicable Applications for EIF4G2 blocking peptide: Western Blot (WB)
• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for EIF4G2 blocking peptide

This is a synthetic peptide designed for use in combination with anti-EIF4G2 antibody made

Target Description: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. EIF4G2 shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, EIF4G2 functions as a general repressor of translation by forming translationally inactive complexes. Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Product Categories/Family for EIF4G2 blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 289577080
• NCBI GeneID: 1982
• NCBI Accession #: NP_001409
• NCBI GenBank Nucleotide #: NM_001418
• UniProt Accession #: P78344
• Molecular Weight: 102kDa
• NCBI Official Full Name: eukaryotic translation initiation factor 4 gamma 2 isoform 1
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4 gamma 2
• NCBI Official Symbol: EIF4G2
• NCBI Official Synonym Symbols: P97; AAG1; DAP5; NAT1
• NCBI Protein Information: eukaryotic translation initiation factor 4 gamma 2
• UniProt Protein Name: Eukaryotic translation initiation factor 4 gamma 2
• Protein Family: Eukaryotic translation initiation factor
• UniProt Gene Name: EIF4G2
• UniProt Synonym Gene Names: DAP5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; DAP-5
• UniProt Entry Name: IF4G2_HUMAN

NCBI Description

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

EIF4G2: a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases.

Protein type: Translation initiation; RNA-binding; Translation

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: membrane; eukaryotic translation initiation factor 4F complex; cytosol

Molecular Function: protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity

Biological Process: cell death; cytokine and chemokine mediated signaling pathway; translational initiation; cell cycle arrest; regulation of translational initiation