Rabbit PER1 Polyclonal Antibody | anti-PER1 antibody

PER1 Antibody - N-terminal region

Cat. Num. AAA3213614

• Gene Names: PER1; PER; hPER; RIGUI
• Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: PER1; Polyclonal Antibody; PER1 Antibody - N-terminal region; anti-PER1 antibody

• Host: Rabbit
• Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity Purified
• Form/Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Sequence: Synthetic peptide located within the following region: SGPLEGADGGGDPRPGESFCPGGVPSPGPPQHRPCPGPSLADDTDANSNG
• Sequence Length: 294

• Applicable Applications for anti-PER1 antibody: Western Blot (WB)
• Homology: Cow: 92%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human PER1
• Preparation and Storage: For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Host: RabbitTarget Name: PER1Sample Type: Thyroid Tumor lysatesAntibody Dilution: 1.0ug/ml)

Related Product Information for anti-PER1 antibody

This is a rabbit polyclonal antibody against PER1. It was validated on Western Blot

Target Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.

Product Categories/Family for anti-PER1 antibody

Polyclonal; Various

NCBI and Uniprot Product Information

• NCBI GI #: 194097341
• NCBI GeneID: 5187
• NCBI Accession #: NP_002607.2
• NCBI GenBank Nucleotide #: NM_002616.2
• UniProt Accession #: O15534
• Molecular Weight: 32kDa
• NCBI Official Full Name: period circadian protein homolog 1
• NCBI Official Synonym Full Names: period circadian regulator 1
• NCBI Official Symbol: PER1
• NCBI Official Synonym Symbols: PER; hPER; RIGUI
• NCBI Protein Information: period circadian protein homolog 1
• UniProt Protein Name: Period circadian protein homolog 1
• Protein Family: Protein
• UniProt Gene Name: PER1
• UniProt Synonym Gene Names: KIAA0482; PER; RIGUI; hPER1
• UniProt Entry Name: PER1_HUMAN

NCBI Description

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014]

Uniprot Description

PER1: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm; nucleus

Molecular Function: signal transducer activity; chromatin DNA binding; ubiquitin protein ligase binding; kinase binding; transcription factor binding

Biological Process: circadian rhythm; negative regulation of JNK cascade; response to cAMP; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; entrainment of circadian clock; regulation of sodium ion transport; circadian regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; signal transduction; regulation of hair cycle; entrainment of circadian clock by photoperiod