Western Blot (WB)
(WB Suggested Anti-NKX2-2 Antibody Titration: 0.125ug/mlELISA Titer: 1:1562500Positive Control: SP2/0 cell lysate)
Rabbit NKX2-2 Polyclonal Antibody | anti-NKX2-2 antibody
NKX2-2 antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-NKX2-2 Antibody Titration: 0.125ug/mlELISA Titer: 1:1562500Positive Control: SP2/0 cell lysate)
Western Blot (WB)
(WB Suggested Anti-NKX2-2 Antibody Titration: 0.125ug/mlELISA Titer: 1:1562500Positive Control: SP2/0 cell lysate)
Target Description: Nkx2-2 contains 1 homeobox DNA-binding domain which is essential for interaction with OLIG2. Nkx2-2 may be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance.
NCBI and Uniprot Product Information
Uniprot Description
NKX2-2: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family.
Protein type: Cell development/differentiation; Transcription factor
Cellular Component: intracellular; nucleus
Molecular Function: chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: astrocyte differentiation; cell development; cell differentiation; endocrine pancreas development; gut development; multicellular organismal development; negative regulation of neuron differentiation; nervous system development; neuron fate specification; oligodendrocyte development; positive regulation of cell differentiation; positive regulation of neuron differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell differentiation; regulation of transcription, DNA-dependent; smoothened signaling pathway; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell differentiation; spinal cord oligodendrocyte cell fate specification; transcription, DNA-dependent
Research Articles on NKX2-2
Similar Products
Product Notes
The NKX2-2 nkx2-2 (Catalog #AAA3203462) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NKX2-2 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's NKX2-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the NKX2-2 nkx2-2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: EGPEEESEGP EPAKRAGPLG QGALDAVQSL PLKSPFYDSS DNPYTRWLAS. It is sometimes possible for the material contained within the vial of "NKX2-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
