Proteinase 3 Antigen (cANCA) Native Protein | KLK3 native protein

Proteinase 3 Antigen (cANCA)

Cat. Num. AAA318126

• Gene Names: KLK3; APS; PSA; hK3; KLK2A1
• Applications: ELISA
• Purity: >90% pure (SDS-PAGE). Column chromatography
• Synonyms: Proteinase 3 Antigen (cANCA); KLK3 native protein

• Host: Human Neutrophils
• Specificity: Proteinase 3 Antigen (cANCA)
• Purity/Purification: >90% pure (SDS-PAGE). Column chromatography
• Form/Format: Purified, Liquid
• Concentration: 0.350mg/ml (BCA) (varies by lot)
• Sequence Length: 238

• Applicable Applications for KLK3 native protein: EIA/ELISA
• Application Notes: ELISA, 1.0-2.0ug/ml coating concentration.; After thawing, mix thoroughly by vortexing before use.; Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in s
• Buffer: 20mM Tris-HCl; 0.4M NaCl, pH 7.6 with 0.02% Lubrol.
• Preservative: Proprietary formula containing 0.1% preservative, bromo-nitro-dioxane/methylisothiazolone
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Warnings: All human source materials have tested negative for HIV 1, HIV 2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infec
• Preparation and Storage: Upon receipt, store at -20 degree C or -70 degree C. Avoid multiple freeze/thaw cycles.

Product Categories/Family for KLK3 native protein

Purified Autoimmune Reagents

NCBI and Uniprot Product Information

• NCBI GI #: 71834853
• NCBI GeneID: 354
• NCBI Accession #: NP_001025218.1
• NCBI GenBank Nucleotide #: NM_001030047.1
• UniProt Accession #: P07288; Q16272; Q86TG8; Q15096; Q15098; Q546G3; Q6LDS3; Q8IXI4; Q8NCW4; Q8WTQ8; Q96A30
• Molecular Weight: 28,741 Da
• NCBI Official Full Name: prostate-specific antigen isoform 3 preproprotein
• NCBI Official Synonym Full Names: kallikrein-related peptidase 3
• NCBI Official Symbol: KLK3
• NCBI Official Synonym Symbols: APS; PSA; hK3; KLK2A1
• NCBI Protein Information: prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen
• UniProt Protein Name: Prostate-specific antigen
• Protein Family: Prostate-specific antigen
• UniProt Gene Name: KLK3
• UniProt Synonym Gene Names: APS
• UniProt Entry Name: KLK3_HUMAN

NCBI Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]

Uniprot Description

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Catalytic activity: Preferential cleavage: -Tyr-|-Xaa-.

Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Ref.18

Subcellular location: Secreted.

Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.

Sequence caution: The sequence AAD14185.1 differs from that shown. Reason: Erroneous initiation.