anti-Human Creatine Kinase MM (CK-MM) Monoclonal Antibody | anti-CKM antibody

MAb to CK-MM

Cat. Num. AAA311597

• Gene Names: CKM; CKMM; M-CK
• Reactivity: Human
• Purity: >90% pure (SDS-PAGE). Protein A chromatography; Product is 0.2um filtered.
• Synonyms: Creatine Kinase MM (CK-MM); Monoclonal Antibody; MAb to CK-MM; Monoclonal Antibody to Human Creatine Kinase MM (CK-MM); anti-CKM antibody

• Host: Host: Mouse; Source: Ascites
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b, kappa
• Clone Number: 027-17186
• Specificity: Creatine Kinase MM (CK-MM); Crossreactivity: CK-MB - 50%; CK-BB - <1%
• Purity/Purification: >90% pure (SDS-PAGE). Protein A chromatography; Product is 0.2um filtered.
• Form/Format: Purified, Liquid
• Concentration: 4.22mg/ml (OD280nm, E^0.1% = 1.4) (varies by lot)
• Sequence Length: 381

• Immunogen: Purified human CK-MM
• Affinity Constant: 3 x 10^9 L/m
• Buffer: 10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
• Preservative: 0.1% Sodium azide
• Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
• Preparation and Storage: Short-term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th

Product Categories/Family for anti-CKM antibody

Monoclonal Antibodies to Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 180588
• NCBI GeneID: 1158
• UniProt Accession #: P06732; Q96QL9
• Molecular Weight: 43,101 Da
• NCBI Official Full Name: creatine kinase
• NCBI Official Synonym Full Names: creatine kinase, muscle
• NCBI Official Symbol: CKM
• NCBI Official Synonym Symbols: CKMM; M-CK
• NCBI Protein Information: creatine kinase M-type; creatine kinase-M; creatine kinase M chain
• UniProt Protein Name: Creatine kinase M-type
• Protein Family: Creatine kinase
• UniProt Gene Name: CKM
• UniProt Synonym Gene Names: CKMM
• UniProt Entry Name: KCRM_HUMAN

NCBI Description

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq]

Uniprot Description

Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Catalytic activity: ATP + creatine = ADP + phosphocreatine.

Subunit structure: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

Subcellular location: Cytoplasm.

Sequence similarities: Belongs to the ATP:guanido phosphotransferase family.Contains 1 phosphagen kinase C-terminal domain.Contains 1 phosphagen kinase N-terminal domain.