Rabbit SLC29A4 Polyclonal Antibody | anti-SLC29A4 antibody

SLC29A4 Polyclonal Antibody

Cat. Num. AAA3015421

• Gene Names: SLC29A4; ENT4; PMAT
• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: SLC29A4; Polyclonal Antibody; SLC29A4 Polyclonal Antibody; Brain transport protein PMAT; ENT 4; ENT4; Equilibrative nucleoside transporter 4; FLJ34923; Plasma membrane monoamine transporter; PMAT; Solute carrier family 29 (nucleoside transporters) member 4; S29A4_HUMAN; Solute carrier family 29 member 4.; anti-SLC29A4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit
• Clonality: Polyclonal
• Specificity: SLC29A4 Polyclonal Antibody detects endogenous levels of SLC29A4 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 140% Glycerol.

• Applicable Applications for anti-SLC29A4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human SLC29A4:401-500/530
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -59 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Primary: Anti-SLC29A4 at 1/1000 dilution)

Related Product Information for anti-SLC29A4 antibody

This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008].

NCBI and Uniprot Product Information

• NCBI GI #: 100913034
• NCBI GeneID: 222962
• NCBI Accession #: NP_001035751
• NCBI GenBank Nucleotide #: NM_001040661.1
• UniProt Accession #: Q7RTT9; Q6PJ08; Q86WY8; Q8NAR3; Q8NBM2
• Molecular Weight: Predicted: 58 kDa; ; Observed: 58 kDa
• NCBI Official Full Name: equilibrative nucleoside transporter 4 isoform 1
• NCBI Official Synonym Full Names: solute carrier family 29 (equilibrative nucleoside transporter), member 4
• NCBI Official Symbol: SLC29A4
• NCBI Official Synonym Symbols: ENT4; PMAT
• NCBI Protein Information: equilibrative nucleoside transporter 4; solute carrier family 29 member 4; plasma membrane monoamine transporter; solute carrier family 29 (nucleoside transporters), member 4
• UniProt Protein Name: Equilibrative nucleoside transporter 4
• Protein Family: Equilibrative nucleoside transporter
• UniProt Gene Name: SLC29A4
• UniProt Synonym Gene Names: ENT4; PMAT; hENT4
• UniProt Entry Name: S29A4_HUMAN

NCBI Description

This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

SLC29A4: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 7p22.1

Cellular Component: apical plasma membrane; integral to membrane; plasma membrane

Molecular Function: nucleoside transmembrane transporter activity; monoamine transmembrane transporter activity

Biological Process: monoamine transport; transmembrane transport