Rabbit AP-2gamma Polyclonal Antibody | anti-AP-2gamma antibody

AP-2gamma Polyclonal Antibody

Cat. Num. AAA3010328

• Gene Names: TFAP2C; ERF1; TFAP2G; hAP-2g; AP2-GAMMA
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: AP-2gamma; Polyclonal Antibody; AP-2gamma Polyclonal Antibody; Transcription factor AP-2 gamma; AP2-gamma; Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1; TFAP2C; AP 2gamma; AP2gamma; anti-AP-2gamma antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: AP-2gamma polyclonal antibody detects endogenous levels of AP-2gamma protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 450

• Applicable Applications for anti-AP-2gamma antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthetic peptide of human TFAP2C
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using TFAP2C antibody.)

Related Product Information for anti-AP-2gamma antibody

AP2 gamma is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.

NCBI and Uniprot Product Information

• NCBI GI #: 4507445
• NCBI GeneID: 7022
• NCBI Accession #: NP_003213.1
• NCBI GenBank Nucleotide #: NP_003213.1
• UniProt Accession #: Q92754
• Molecular Weight: ~ 49kDa
• NCBI Official Full Name: transcription factor AP-2 gamma
• NCBI Official Synonym Full Names: transcription factor AP-2 gamma
• NCBI Official Symbol: TFAP2C
• NCBI Official Synonym Symbols: ERF1; TFAP2G; hAP-2g; AP2-GAMMA
• NCBI Protein Information: transcription factor AP-2 gamma
• UniProt Protein Name: Transcription factor AP-2 gamma
• UniProt Gene Name: TFAP2C
• UniProt Synonym Gene Names: AP2-gamma
• UniProt Entry Name: AP2C_HUMAN

NCBI Description

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

Uniprot Description

AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family.

Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleus

Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; somatic stem cell maintenance; male gonad development; sebaceous gland development; germ-line stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; trophectodermal cell differentiation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; hair follicle development; cell-cell signaling; positive regulation of transcription from RNA polymerase II promoter; forebrain neuron fate commitment; cerebral cortex development; regulation of epidermis development