Rabbit CLIP2 Polyclonal Antibody | anti-CLIP2 antibody

CLIP2 Polyclonal Antibody

Cat. Num. AAA3007536

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CLIP2; Polyclonal Antibody; CLIP2 Polyclonal Antibody; CAP-Gly domain-containing linker protein 2; Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndrome chromosomal region 4 protein; CYLN2; KIAA0291; WBSCR3; WBSCR4; WSCR4; anti-CLIP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CLIP2 polyclonal antibody detects endogenous levels of CLIP2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1046

• Applicable Applications for anti-CLIP2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding Human CLIP2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CLIP2 polyclonal antibody at 1:500 dilutionLane1:AML-12 whole cell lysate (40ug) Lane2:PC12 whole cell lysate (40ug) Lane3:A549 whole cell lysate (40ug) Lane4:L02 whole cell lysate (40ug) Lane5:Hela whole cell lysate (40ug))

Related Product Information for anti-CLIP2 antibody

Williams Syndrome (WS) is a developmental disorder characterized by cardiovascular problems, dysmorphic features, mental retardation or learning difficulties and several typical behavioral and neurological abnormalities. In Williams Syndrome patients, a heterozygous deletion is present in a region on chromosome 7q11.23 (the Williams Syndrome critical region), which spans approximately 20 genes. This region comprises the CYLN2 gene, which encodes the cytoplasmic linker protein of (CLIP-115). CLIP-115 is a microtubule-binding protein that is abundantly expressed in the brain. Mice with haploinsufficiency for the CYLN2 gene have features similar to that of WS, including mild growth deficiency, brain abnormalities, hippocampal dysfunction and particular deficits in motor coordination.

NCBI and Uniprot Product Information

• NCBI GI #: 116008447
• NCBI Accession #: NP_003379.3
• NCBI GenBank Nucleotide #: NP_003379.3
• UniProt Accession #: Q9UDT6
• Molecular Weight: ~ 115kDa
• NCBI Official Full Name: CAP-Gly domain-containing linker protein 2 isoform 1
• UniProt Protein Name: CAP-Gly domain-containing linker protein 2
• Protein Family: CAP-Gly domain-containing linker protein
• UniProt Gene Name: CLIP2
• UniProt Synonym Gene Names: CYLN2; KIAA0291; WBSCR3; WBSCR4; WSCR4; CLIP-115
• UniProt Entry Name: CLIP2_HUMAN

Uniprot Description

CYLN2: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations. CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: microtubule associated complex; cytoplasmic microtubule

Molecular Function: microtubule plus-end binding