Rabbit RND2 Polyclonal Antibody | anti-RND2 antibody

RND2 Polyclonal Antibody

Cat. Num. AAA3006874

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: RND2; Polyclonal Antibody; RND2 Polyclonal Antibody; Rho-related GTP-binding protein RhoN; Rho family GTPase 2; Rho-related GTP-binding protein Rho7; Rnd2; ARHN; RHO7; anti-RND2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: RND2 polyclonal antibody detects endogenous levels of RND2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 227

• Applicable Applications for anti-RND2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human RND2
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of RND2 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate)

Related Product Information for anti-RND2 antibody

The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.

NCBI and Uniprot Product Information

• NCBI GI #: 4885581
• NCBI Accession #: NP_005431.1
• NCBI GenBank Nucleotide #: NP_005431.1
• UniProt Accession #: P52198
• Molecular Weight: ~ 25kDa
• NCBI Official Full Name: rho-related GTP-binding protein RhoN
• UniProt Protein Name: Rho-related GTP-binding protein RhoN
• Protein Family: Rho-related GTP-binding protein
• UniProt Gene Name: RND2
• UniProt Synonym Gene Names: ARHN; RHO7
• UniProt Entry Name: RND2_HUMAN

Uniprot Description

RND2: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily. Belongs to the small GTPase superfamily. Rho family.

Protein type: G protein, monomeric; G protein; G protein, monomeric, Rho

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: early endosome; acrosomal membrane

Molecular Function: GTPase activity; protein binding; GTP binding; protein N-terminus binding

Biological Process: metabolic process; small GTPase mediated signal transduction; signal transduction; positive regulation of collateral sprouting