Rabbit Opticin Polyclonal Antibody | anti-Opticin antibody

Opticin Polyclonal Antibody

Cat. Num. AAA3006596

• Gene Names: OPTC; OPT
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Opticin; Polyclonal Antibody; Opticin Polyclonal Antibody; Oculoglycan; OPTC; OPT; anti-Opticin antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Opticin polyclonal antibody detects endogenous levels of Opticin protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 332

• Applicable Applications for anti-Opticin antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human Opticin.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Opticin polyclonal antibody at 1:500 dilutionLane1:Hela cell lysate Lane2:Mouse heart tissue lysateLane3:Rat heart tissue lysate)

Related Product Information for anti-Opticin antibody

Opticin, also known as OPTC or OPT, is a 332 amino acid protein that is secreted into the extracellular matrix and contains seven LRR repeats. Expressed in skin and fetal liver and also present in ocular tissues, such as the retina, cornea and iris, opticin functions to bind collagen fibrils and, via this interaction, is thought to regulate fibril spacing, morphology and organization. Opticin is subject to post-translational O-glycosylation and may be associated with the pathogenesis of primary open angle glaucoma.

NCBI and Uniprot Product Information

• NCBI GI #: 7657419
• NCBI GeneID: 26254
• NCBI Accession #: NP_055174.1
• NCBI GenBank Nucleotide #: NP_055174.1
• UniProt Accession #: Q9UBM4
• Molecular Weight: ~ 40kDa
• NCBI Official Full Name: opticin
• NCBI Official Synonym Full Names: opticin
• NCBI Official Symbol: OPTC
• NCBI Official Synonym Symbols: OPT
• NCBI Protein Information: opticin
• UniProt Protein Name: Opticin
• Protein Family: Opticin
• UniProt Gene Name: OPTC
• UniProt Synonym Gene Names: OPT
• UniProt Entry Name: OPT_HUMAN

NCBI Description

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008]

Uniprot Description

OPTC: Binds collagen fibrils. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32.1

Molecular Function: extracellular matrix structural constituent