NOR-1 blocking peptide

NOR-1 (Y419) Peptide

Cat. Num. AAA3004439

• Gene Names: NR4A3; CHN; TEC; CSMF; NOR1; MINOR
• Applications: Blocking
• Purity: Synthetic peptide NOR-1 (Y419). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: NOR-1; NOR-1 (Y419) Peptide; CHN; Chondrosarcoma; extraskeletal myxoid; fused to EWS; CSMF; MINOR; Mitogen induced nuclear orphan receptor; Mitogen-induced nuclear orphan receptor; Neuron derived orphan receptor 1; Neuron derived orphan receptor; Neuron-derived orphan receptor 1; NOR1; Nr4a3; NR4A3; Nuclear hormone receptor NOR-1; Nuclear hormone receptor NOR1; Nuclear receptor subfamily 4 group A member 3; TEC; Translocated in extraskeletal chondrosarcoma; NOR-1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3004438 NOR-1 (Y419) pAb.
• Purity/Purification: Synthetic peptide NOR-1 (Y419). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 626

• Applicable Applications for NOR-1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for NOR-1 blocking peptide

Nur77 (also designated NGFI-B), Nurr1 (Nur-related factor 1) and NOR-1 (neuron-derived orphan receptor-1) constitute the NGFI-B subfamily within the nuclear receptor superfamily.The human NOR-1 gene maps to chromosome 9q and encodes a protein which is expressed in heart, skeletal muscle, thymus and spleen as well as in brain, where it is developmentally regulated. Therefore, NOR-1 may be involved in regulating neural differentiation. The NOR-1 gene also undergoes chromosomal translocation with the EWS gene to produce a protein thought to affect pre-mRNA splicing.

NCBI and Uniprot Product Information

• NCBI GI #: 27894355
• NCBI GeneID: 8013
• NCBI Accession #: NP_008912.2
• NCBI GenBank Nucleotide #: NP_008912.2
• UniProt Accession #: Q92570
• NCBI Official Full Name: nuclear receptor subfamily 4 group A member 3 isoform a
• NCBI Official Synonym Full Names: nuclear receptor subfamily 4 group A member 3
• NCBI Official Symbol: NR4A3
• NCBI Official Synonym Symbols: CHN; TEC; CSMF; NOR1; MINOR
• NCBI Protein Information: nuclear receptor subfamily 4 group A member 3
• UniProt Protein Name: Nuclear receptor subfamily 4 group A member 3
• Protein Family: Norsolorinic acid ketoreductase
• UniProt Gene Name: NR4A3
• UniProt Synonym Gene Names: CHN; CSMF; MINOR; NOR1; TEC
• UniProt Entry Name: NR4A3_HUMAN

NCBI Description

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Description

NR4A3: Binds to the B1A response-element. Defects in NR4A3 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1. A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N. Belongs to the nuclear hormone receptor family. NR4 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity

Biological Process: response to peptide hormone stimulus; axon guidance; transcription initiation from RNA polymerase II promoter; organ regeneration; intracellular receptor-mediated signaling pathway; hippocampus development; semicircular canal morphogenesis; positive regulation of cell cycle; response to hydrogen peroxide; mesoderm formation; vestibular reflex; adult behavior; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; negative regulation of neuron apoptosis; neuromuscular process controlling balance

Disease: Chondrosarcoma, Extraskeletal Myxoid