PSMD12 blocking peptide

PSMD12 (I186) Peptide

Cat. Num. AAA3004296

• Gene Names: PSMD12; p55; Rpn5; STISS
• Applications: Blocking
• Purity: Synthetic peptide PSMD12 (I186). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: PSMD12; PSMD12 (I186) Peptide; 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; MGC75406; proteasome (prosome; macropain) 26S subunit; non ATPase12; Proteasome 26S non ATPase subunit 12 isoform 2; PSD12; Rpn5; PSMD12 blocking peptide

• Specificity: This peptide can be used with studies using MBS3004295 PSMD12 (I186) pAb.
• Purity/Purification: Synthetic peptide PSMD12 (I186). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 456

• Applicable Applications for PSMD12 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for PSMD12 blocking peptide

PSMD12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12), also known as p55 or Rpn5, is a 456 amino acid protein belonging to the proteasome subunit p55 family. PSMD12 acts as a regulatory subunit of the 26S Proteasome and is a component of the PA700 complex. PSMD12 contains one PCI domain.

NCBI and Uniprot Product Information

• NCBI GI #: 4506221
• NCBI GeneID: 5718
• NCBI Accession #: NP_002807.1
• NCBI GenBank Nucleotide #: NP_002807.1
• UniProt Accession #: O00232
• NCBI Official Full Name: 26S proteasome non-ATPase regulatory subunit 12 isoform 1
• NCBI Official Synonym Full Names: proteasome 26S subunit, non-ATPase 12
• NCBI Official Symbol: PSMD12
• NCBI Official Synonym Symbols: p55; Rpn5; STISS
• NCBI Protein Information: 26S proteasome non-ATPase regulatory subunit 12
• UniProt Protein Name: 26S proteasome non-ATPase regulatory subunit 12
• Protein Family: 26S proteasome non-ATPase regulatory
• UniProt Gene Name: PSMD12
• UniProt Entry Name: PSD12_HUMAN

NCBI Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Description

PSMD12: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit p55 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: proteasome complex; nucleoplasm; membrane; proteasome regulatory particle; cytosol

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis