NCoA-3 blocking peptide

NCoA-3 (S587) Peptide

Cat. Num. AAA3003861

• Gene Names: NCOA3; ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
• Applications: Blocking
• Purity: Synthetic peptide NCoA-3 (S587). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: NCoA-3; NCoA-3 (S587) Peptide; Nuclear receptor coactivator 3; EC=2.3.1.48; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1; AIB1; BHLHE42; RAC3; TRAM1; NCOA3; NCoA-3 blocking peptide

• Specificity: This peptide can be used with studies using MBS3003860 NCoA-3 (S587) pAb.
• Purity/Purification: Synthetic peptide NCoA-3 (S587). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1423

• Applicable Applications for NCoA-3 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for NCoA-3 blocking peptide

Several related transcriptional coactivators and corepressors have been described that work in concert with the steroid receptor family to either induce or repress transcription from hormone-responsive elements. This family includes GRIP1 (for GR interacting protein 1), also designated NCoA-2 or TIF-2; SRC-1 (for steroid receptor coactivator-1), also designated NCoA-1; and NCoA-3, also designated RAC3, ACTR, AIB-1 (for amplified in breast cancer) and p/CIP (for p300/CBP/co-integrator protein), which displays elevated expression in estrogen receptor positive ovarian and breast cancers and is required for the transcriptional activation of p300/CBP-dependent transcription factors.

NCBI and Uniprot Product Information

• NCBI GI #: 291490683
• NCBI GeneID: 8202
• NCBI Accession #: NP_001167558.1
• NCBI GenBank Nucleotide #: NP_001167558.1
• UniProt Accession #: Q9Y6Q9
• NCBI Official Full Name: nuclear receptor coactivator 3 isoform c
• NCBI Official Synonym Full Names: nuclear receptor coactivator 3
• NCBI Official Symbol: NCOA3
• NCBI Official Synonym Symbols: ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
• NCBI Protein Information: nuclear receptor coactivator 3
• UniProt Protein Name: Nuclear receptor coactivator 3
• UniProt Gene Name: NCOA3
• UniProt Synonym Gene Names: AIB1; BHLHE42; RAC3; TRAM1; NCoA-3; AIB-1; pCIP; bHLHe42; RAC-3; SRC-3; TRAM-1
• UniProt Entry Name: NCOA3_HUMAN

NCBI Description

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]