TRH-R1 blocking peptide

TRH-R1 (W234) Peptide

Cat. Num. AAA3003546

• Gene Names: TRHR; CHNG7; TRH-R
• Applications: Blocking
• Purity: Synthetic peptide TRH-R1 (W234). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: TRH-R1; TRH-R1 (W234) Peptide; Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor; TRHR; TRH-R1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3003545 TRH-R1 (W234) pAb.
• Purity/Purification: Synthetic peptide TRH-R1 (W234). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 398

• Applicable Applications for TRH-R1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for TRH-R1 blocking peptide

Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide that stimulates, via its receptor in the anterior pituitary gland, the release of thyrotrophin (TSH) and prolactin. The TRH receptors, TRH-R1 and TRH-R2, are G protein-coupled proteins containing seven transmembrane domains and other conserved regions. In rat, two isoforms exist, TRH-R (412) and TRH-R (387), that differ at their carboxy termini. TRH receptors are distributed throughout the central and peripheral nervous systems and are present in a variety of tissues. TRH-R2 displays 50% homology to TRH-R1 and is more restricted to the central nervous system than TRH-R1. Mutation in the TRH receptor gene is associated with isolated central hypothyroidism, a rare disorder characterized by insufficient TSH secretion resulting in low levels of thyroid hormones.

NCBI and Uniprot Product Information

• NCBI GI #: 4507681
• NCBI GeneID: 7201
• NCBI Accession #: NP_003292.1
• NCBI GenBank Nucleotide #: NP_003292.1
• UniProt Accession #: P34981
• NCBI Official Full Name: thyrotropin-releasing hormone receptor
• NCBI Official Synonym Full Names: thyrotropin releasing hormone receptor
• NCBI Official Symbol: TRHR
• NCBI Official Synonym Symbols: CHNG7; TRH-R
• NCBI Protein Information: thyrotropin-releasing hormone receptor
• UniProt Protein Name: Thyrotropin-releasing hormone receptor
• UniProt Gene Name: TRHR
• UniProt Synonym Gene Names: TRH-R
• UniProt Entry Name: TRFR_HUMAN

NCBI Description

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

Uniprot Description

TRHR: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q23

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: thyrotropin-releasing hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway