Rabbit GnRH I Polyclonal Antibody | anti-GnRHI antibody

GnRH I (D43) Polyclonal Antibody

Cat. Num. AAA3003156

• Gene Names: GNRH1; GRH; GNRH; LHRH; LNRH
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GnRH I; Polyclonal Antibody; GnRH I (D43) Polyclonal Antibody; Progonadoliberin-1; Progonadoliberin I; Gonadoliberin-1; Gonadoliberin I; Gonadorelin; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH I; GnRH-associated peptide 1; GnRH-associated peptide I; GNRH1; GNRH; GRH; LHRH; anti-GnRHI antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GnRH I (D43) polyclonal antibody detects endogenous levels of GnRH I protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 92

• Applicable Applications for anti-GnRHI antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 11-60 of Human GnRH I.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Testing Data

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of GnRH I (D43) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.)

Related Product Information for anti-GnRHI antibody

GnRH is produced by hypothalamic neurons and secreted in a pulsatile manner into the capillary plexus of the median eminence. GnRH affects the release of lutenizing hormone and follicle stimulating hormone from gonadotropic cells in the anterior pituitary. In addition to hypothalamic GnRH (GnRH I), a second GnRH form (GnRH II) functions primarily in the midbrain. GnRH is xpressed in the acrosomal region of human sperm and in the anterior pituitary tissue and cancer cells. Unlike GnRH I, GnRH II is highly expressed outside the brain, particularly in the kidney, bone marrow and prostate, suggesting that it may have multiple functions. GnRH binds to a specific G protein-coupled receptor in the pituitary to regulate synthesis and secretion of gonadotropins.

NCBI and Uniprot Product Information

• NCBI GI #: 133908612
• NCBI GeneID: 2796
• NCBI Accession #: NP_001076580.1
• NCBI GenBank Nucleotide #: NP_001076580.1
• UniProt Accession #: P01148
• Molecular Weight: ~ 11kDa
• NCBI Official Full Name: progonadoliberin-1 isoform 2 preproprotein
• NCBI Official Synonym Full Names: gonadotropin releasing hormone 1
• NCBI Official Symbol: GNRH1
• NCBI Official Synonym Symbols: GRH; GNRH; LHRH; LNRH
• NCBI Protein Information: progonadoliberin-1
• UniProt Protein Name: Progonadoliberin-1
• UniProt Gene Name: GNRH1
• UniProt Synonym Gene Names: GNRH; GRH; LHRH; GnRH-I; LH-RH I
• UniProt Entry Name: GON1_HUMAN

NCBI Description

This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]

Uniprot Description

GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.

Protein type: Hormone; Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21-p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; luteinizing hormone-releasing factor activity

Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; negative regulation of apoptosis; response to corticosteroid stimulus

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia