Bovine Nuclear Antibody ELISA Kit | ANA elisa kit

Bovine Nuclear Antibody ELISA Kit

Cat. Num. AAA29457

• Gene Names: NUMA1; NUMA
• Reactivity: Bovine
• Synonyms: Nuclear Antibody; Bovine Nuclear Antibody ELISA Kit; ANA elisa kit

• Reactivity: Bovine
• Sequence Length: 2115

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 71361682
• NCBI GeneID: 4926
• NCBI Accession #: NP_006176.2
• NCBI GenBank Nucleotide #: NM_006185.3
• UniProt Accession #: Q14980; Q14981; Q9BTE9; H0YH75
• Molecular Weight: 238,260 Da
• NCBI Official Full Name: nuclear mitotic apparatus protein 1 isoform 1
• NCBI Official Synonym Full Names: nuclear mitotic apparatus protein 1
• NCBI Official Symbol: NUMA1
• NCBI Official Synonym Symbols: NUMA
• NCBI Protein Information: nuclear mitotic apparatus protein 1; SP-H antigen; structural nuclear protein; centrophilin stabilizes mitotic spindle in mitotic cells
• UniProt Protein Name: Nuclear mitotic apparatus protein 1
• Protein Family: Protein anachronism
• UniProt Gene Name: NUMA1
• UniProt Synonym Gene Names: NUMA; NuMA protein
• UniProt Entry Name: NUMA1_HUMAN

NCBI Description

This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Uniprot Description

NuMA-1: a coiled-coil nuclear protein that is required to establish and maintain mammalian spindle poles. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. Two human splice-variant isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi membrane; nucleoplasm; spindle pole; nuclear matrix; cell soma; spindle microtubule; apical part of cell; dendrite; cytoplasm; spindle; chromosome; nucleus; cytosol

Molecular Function: protein binding; microtubule binding; structural molecule activity

Biological Process: mitosis; meiotic cell cycle; establishment of mitotic spindle orientation; cell division; mitotic cell cycle; G2/M transition of mitotic cell cycle; nuclear organization and biogenesis

Disease: Acute Promyelocytic Leukemia