Mouse Per1/Period circadian protein homolog 1 ELISA Kit | Per1 elisa kit

Mouse Per1/Period circadian protein homolog 1 ELISA Kit

Cat. Num. AAA2904810

• Gene Names: Per1; Per; mPer1; m-rigui
• Reactivity: Mouse
• Synonyms: Per1/Period circadian protein homolog 1; Mouse Per1/Period circadian protein homolog 1 ELISA Kit; mPER1; Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui; Per; Rigui; Period circadian protein homolog 1; Per1 elisa kit

• Reactivity: Mouse
• Specificity: Natural and recombinant Mouse Period circadian protein homolog 1

• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 226823279
• NCBI GeneID: 18626
• NCBI Accession #: NP_001152839.1
• NCBI GenBank Nucleotide #: NM_001159367.1
• UniProt Accession #: O35973; B1ASX0
• Molecular Weight: 136,373 Da
• NCBI Official Full Name: period circadian protein homolog 1
• NCBI Official Synonym Full Names: period circadian clock 1
• NCBI Official Symbol: Per1
• NCBI Official Synonym Symbols: Per; mPer1; m-rigui
• NCBI Protein Information: period circadian protein homolog 1; circadian clock protein PERIOD 1; circadian pacemaker protein Rigui; period homolog 1
• UniProt Protein Name: Period circadian protein homolog 1
• Protein Family: Protein
• UniProt Gene Name: Per1
• UniProt Synonym Gene Names: Per; Rigui; mPER1
• UniProt Entry Name: PER1_MOUSE

NCBI Description

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]

Uniprot Description

PER1: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; signal transducer activity; chromatin DNA binding; ubiquitin protein ligase binding; transcription factor binding; kinase binding

Biological Process: circadian rhythm; negative regulation of JNK cascade; response to cAMP; transcription, DNA-dependent; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; regulation of sodium ion transport; negative regulation of I-kappaB kinase/NF-kappaB cascade; regulation of circadian rhythm; signal transduction; entrainment of circadian clock by photoperiod; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of hair cycle