MS4A2 / High Affinity Immunoglobulin Epsilon Receptor Subunit Beta Recombinant Protein | MS4A2 recombinant protein
Human MS4A2 / High Affinity Immunoglobulin Epsilon Receptor Subunit Beta Recombinant Protein
Gene Names
MS4A2; APY; IGEL; IGER; ATOPY; FCERI; IGHER; MS4A1; FCER1B
Applications
ELISA, Western Blot
Purity
>95% by SDS-PAGE
Synonyms
MS4A2 / High Affinity Immunoglobulin Epsilon Receptor Subunit Beta; Human MS4A2 / High Affinity Immunoglobulin Epsilon Receptor Subunit Beta Recombinant Protein; High affinity immunoglobulin epsilon receptor subunit beta; FcERI; Fc epsilon receptor I beta-chain; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 2; APY; FCER1B; IGER; MS4A2 recombinant protein
Host
E Coli
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
Concentration
Reconstitution Dependent (varies by lot)
Sequence Length
244
Applicable Applications for MS4A2 recombinant protein
ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
Species
Human
Tag
His
Subunit
Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN.
Entry Function
High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
Preparation and Storage
Store at -20 degree C. Avoid repeated freezing and thawing.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
high affinity immunoglobulin epsilon receptor subunit beta isoform 1
NCBI Official Synonym Full Names
membrane spanning 4-domains A2
NCBI Official Symbol
MS4A2
NCBI Official Synonym Symbols
APY; IGEL; IGER; ATOPY; FCERI; IGHER; MS4A1; FCER1B
NCBI Protein Information
high affinity immunoglobulin epsilon receptor subunit beta
UniProt Protein Name
High affinity immunoglobulin epsilon receptor subunit beta
Protein Family
UniProt Gene Name
MS4A2
UniProt Synonym Gene Names
APY; FCER1B; IGER; FcERI
UniProt Entry Name
FCERB_HUMAN
NCBI Description
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
Research Articles on MS4A2
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Product Notes
The MS4A2 ms4a2 (Catalog #AAA2903050) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MS4A2 / High Affinity Immunoglobulin Epsilon Receptor Subunit Beta can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array. Researchers should empirically determine the suitability of the MS4A2 ms4a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MS4A2 / High Affinity Immunoglobulin Epsilon Receptor Subunit Beta, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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