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MTDH / Protein LYRIC Recombinant Protein | MTDH recombinant protein

Human MTDH / Protein LYRIC Recombinant Protein

Gene Names
MTDH; 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
Applications
ELISA, Western Blot
Purity
>95% by SDS-PAGE
Synonyms
MTDH / Protein LYRIC; Human MTDH / Protein LYRIC Recombinant Protein; Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; AEG1; LYRIC; MTDH recombinant protein
Ordering
Host
E Coli
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
Concentration
Reconstitution Dependent (varies by lot)
Sequence Length
582
Applicable Applications for MTDH recombinant protein
ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
Species
Human
Tag
His
Subunit
Interacts with BCCIP, CREBBP/CBP and RELA/p65.
Entry Function
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Preparation and Storage
Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
protein LYRIC isoform 1
NCBI Official Synonym Full Names
metadherin
NCBI Official Symbol
MTDH
NCBI Official Synonym Symbols
3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
NCBI Protein Information
protein LYRIC
UniProt Protein Name
Protein LYRIC
Protein Family
UniProt Gene Name
MTDH
UniProt Synonym Gene Names
AEG1; LYRIC; AEG-1
UniProt Entry Name
LYRIC_HUMAN

Uniprot Description

Lyric: a protein of unknown function.

Protein type: Cell adhesion; Nucleolus; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: apical plasma membrane; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; intercellular canaliculus; nuclear body; nuclear membrane; nucleolus; nucleus; perinuclear region of cytoplasm; tight junction

Molecular Function: double-stranded RNA binding; NF-kappaB binding; protein binding; transcription coactivator activity

Biological Process: activation of NF-kappaB transcription factor; lipopolysaccharide-mediated signaling pathway; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein kinase B signaling cascade

Research Articles on MTDH

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Product Notes

The MTDH mtdh (Catalog #AAA2902556) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MTDH / Protein LYRIC can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array. Researchers should empirically determine the suitability of the MTDH mtdh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MTDH / Protein LYRIC, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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