MR1 / Major Histocompatibility Complex Class I-Related Gene Protein Recombinant Protein | MR1 recombinant protein

Human MR1 / Major Histocompatibility Complex Class I-Related Gene Protein Recombinant Protein

• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: MR1 / Major Histocompatibility Complex Class I-Related Gene Protein; Human MR1 / Major Histocompatibility Complex Class I-Related Gene Protein Recombinant Protein; Major histocompatibility complex class I-related gene protein; MHC class I-related gene protein; Class I histocompatibility antigen-like protein; MR1 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 341

• Applicable Applications for MR1 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and doesn't associates with B2M nor proteins of the peptide-loading complex.
• Entry Function: Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 4504417
• NCBI Accession #: NP_001522.1
• NCBI GenBank Nucleotide #: NP_001522.1
• UniProt Accession #: Q95460
• NCBI Official Full Name: major histocompatibility complex class I-related gene protein isoform 1
• UniProt Protein Name: Major histocompatibility complex class I-related gene protein
• Protein Family: Major histocompatibility complex class I-related gene protein
• UniProt Gene Name: MR1
• UniProt Synonym Gene Names: MHC class I-related gene protein
• UniProt Entry Name: HMR1_HUMAN

Uniprot Description

MR1: Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. Belongs to the MHC class I family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.3

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; extracellular region; integral to membrane; plasma membrane; MHC class I protein complex

Molecular Function: MHC class I receptor activity; peptide antigen binding; antigen binding

Biological Process: antigen processing and presentation; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; interleukin-17 production; interleukin-1 beta production; innate immune response; immune response; cytokine production during immune response; signal transduction; defense response to Gram-negative bacterium