C1QC / Complement C1q Subcomponent Subunit C Recombinant Protein | C1QC recombinant protein

Human C1QC / Complement C1q Subcomponent Subunit C Recombinant Protein

• Gene Names: C1QC; C1QG; C1Q-C
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: C1QC / Complement C1q Subcomponent Subunit C; Human C1QC / Complement C1q Subcomponent Subunit C Recombinant Protein; Complement C1q subcomponent subunit C; C1QG; C1QC recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 245

• Applicable Applications for C1QC recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.
• Entry Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 166235903
• NCBI GeneID: 714
• NCBI Accession #: NP_001107573.1
• NCBI GenBank Nucleotide #: NP_001107573.1
• UniProt Accession #: P02747
• NCBI Official Full Name: complement C1q subcomponent subunit C isoform 1
• NCBI Official Synonym Full Names: complement C1q C chain
• NCBI Official Symbol: C1QC
• NCBI Official Synonym Symbols: C1QG; C1Q-C
• NCBI Protein Information: complement C1q subcomponent subunit C
• UniProt Protein Name: Complement C1q subcomponent subunit C
• Protein Family: Complement C1q subcomponent
• UniProt Gene Name: C1QC
• UniProt Synonym Gene Names: C1QG
• UniProt Entry Name: C1QC_HUMAN

NCBI Description

This gene encodes the C-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]

Uniprot Description

C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extracellular space; collagen; extracellular region

Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; negative regulation of granulocyte differentiation; complement activation

Disease: C1q Deficiency