PROK1 / Prokineticin-1 Recombinant Protein | PROK1 recombinant protein

Human PROK1 / Prokineticin-1 Recombinant Protein

• Gene Names: PROK1; PK1; PRK1; EGVEGF
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: PROK1 / Prokineticin-1; Human PROK1 / Prokineticin-1 Recombinant Protein; Prokineticin-1; Endocrine-gland-derived vascular endothelial growth factor; EG-VEGF; Mambakine; UNQ600/PRO1186; PROK1 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 105

• Applicable Applications for PROK1 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Entry Function: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 37182488
• NCBI GeneID: 84432
• UniProt Accession #: P58294
• NCBI Official Full Name: EG-VEGF
• NCBI Official Synonym Full Names: prokineticin 1
• NCBI Official Symbol: PROK1
• NCBI Official Synonym Symbols: PK1; PRK1; EGVEGF
• NCBI Protein Information: prokineticin-1
• UniProt Protein Name: Prokineticin-1
• Protein Family: Prokineticin
• UniProt Gene Name: PROK1
• UniProt Synonym Gene Names: EG-VEGF
• UniProt Entry Name: PROK1_HUMAN

NCBI Description

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

Uniprot Description

PROK1: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. Belongs to the AVIT (prokineticin) family.

Protein type: Secreted; Secreted, signal peptide; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: extracellular region

Molecular Function: growth factor activity

Biological Process: activation of MAPK activity; positive regulation of cell division; positive regulation of cell proliferation; angiogenesis; regulation of angiogenesis