NCBI and Uniprot Product Information
NCBI Description
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with multiple psychiatric disorders and play a causal role in CHARGE syndrome in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, Nov 2015]
Uniprot Description
CDH7: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 18q22.1
Cellular Component: integral to membrane; plasma membrane
Molecular Function: calcium ion binding
Biological Process: cell-cell adhesion; homophilic cell adhesion; intercellular junction assembly and maintenance