Typical Testing Data/Standard Curve (for reference only)
Mouse KiSS-1 receptor ELISA Kit | Kiss1r elisa kit
Mouse KiSS-1 receptor ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
KISS1R: Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine- tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. Defects in KISS1R are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in KISS1R are a cause of central precocious puberty (CEPREPU). Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Central precocious puberty refers to a gonadotropin-dependent type which results from premature activation of the hypothalamic-pituitary-gonadal axis. Belongs to the G-protein coupled receptor 1 family.
Protein type: Cell cycle regulation; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Cellular Component: cell surface; integral to membrane; integral to plasma membrane; intracellular; intracellular membrane-bound organelle; membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; neuropeptide binding; neuropeptide receptor activity; peptide receptor activity, G-protein coupled; protein binding; signal transducer activity
Biological Process: activation of MAPKK activity; arachidonic acid secretion; calcium-mediated signaling; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of cell migration; negative regulation of cell proliferation; neuropeptide signaling pathway; positive regulation of hormone secretion; positive regulation of stress fiber formation; positive regulation of synaptic transmission; signal transduction
Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Research Articles on Kiss1r
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Product Notes
The Mouse Kiss1r kiss1r (Catalog #AAA2882826) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2882826 ELISA Kit recognizes Mouse Kiss1r. It is sometimes possible for the material contained within the vial of "KiSS-1 receptor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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