Mouse ADP-ribosyl cyclase 1 ELISA Kit | Cd38 elisa kit

Mouse ADP-ribosyl cyclase 1 ELISA Kit

Cat. Num. AAA2880986

• Gene Names: Cd38; I-19; ADPRC 1; Cd38-rs1
• Reactivity: Mouse
• Synonyms: ADP-ribosyl cyclase 1; Mouse ADP-ribosyl cyclase 1 ELISA Kit; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; I-19; NIM-R5 antigen; Cd38; 3.2.2.5; CD38; Cd38 elisa kit

• Reactivity: Mouse
• Sequence Length: 304

• Assay Type: Sandwich
• Detection Range: 0.78-50 ng/mL
• Sensitivity: 0.393 ng/mL
• Intra-Assay CV: <=8.3%
• Inter-Assay CV: <=10.1%
• Recovery: 93%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 31542362
• NCBI GeneID: 12494
• NCBI Accession #: NP_031672.2
• NCBI GenBank Nucleotide #: NM_007646.5
• UniProt Accession #: P56528; Q8BFY8
• Molecular Weight: 34,408 Da
• NCBI Official Full Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• NCBI Official Synonym Full Names: CD38 antigen
• NCBI Official Symbol: Cd38
• NCBI Official Synonym Symbols: I-19; ADPRC 1; Cd38-rs1
• NCBI Protein Information: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• UniProt Protein Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• Protein Family: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
• UniProt Gene Name: Cd38
• UniProt Synonym Gene Names: ADPRC 1; cADPr hydrolase 1
• UniProt Entry Name: CD38_MOUSE

NCBI Description

This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]

Uniprot Description

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Apoptosis; EC 2.4.99.20; EC 3.2.2.6; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cell cycle regulation; Membrane protein, integral; Lyase; Hydrolase

Cellular Component: cell surface; cytosol; integral to membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane

Molecular Function: hydrolase activity; hydrolase activity, acting on glycosyl bonds; NAD(P)+ nucleosidase activity; NAD+ nucleosidase activity; phosphorus-oxygen lyase activity; transferase activity

Biological Process: B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; negative regulation of apoptosis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of insulin secretion; positive regulation of transcription, DNA-dependent; positive regulation of vasoconstriction; response to drug; response to hormone stimulus; response to hydroperoxide; response to hypoxia