Mouse Potassium voltage-gated channel subfamily H member 2 (KCNH2) ELISA Kit | KCNH2 elisa kit
Mouse Potassium voltage-gated channel subfamily H member 2 (KCNH2) ELISA Kit
Gene Names
Kcnh2; LQT; ERG1; Lqt2; M-erg; Merg1; merg1a; merg1b; AI326795
Reactivity
Mouse
Synonyms
Potassium voltage-gated channel subfamily H member 2 (KCNH2); Mouse Potassium voltage-gated channel subfamily H member 2 (KCNH2) ELISA Kit; ERG1; HERG; HERG1; Kv11.1; LQT2; SQT1; ether-a-go-go-related potassium channel protein; potassium voltage-gated channel subfamily H member 2; voltage-gated potassium channel; subfamily H; member 2; KCNH2 elisa kit
Reactivity
Mouse
Specificity
This assay has high sensitivity and excellent specificity for detection of Mouse KCNH2. No significant cross-reactivity or interference between Mouse KCNH2 and analogues was observed.
Sequence Length
820
Assay Type
Quantitive Sandwich
Samples
Serum, Plasma, Other Biological Fluids
Detection Wavelength
450 nm
Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%)
= SD/meanX100
Intra-Assay
CV
Inter-Assay
CV
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for KCNH2 elisa kit
Description: This assay employs a two-site sandwich ELISA to quantitate KCNH2 in samples. An antibody specific for KCNH2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any KCNH2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KCNH2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KCNH2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Overview: 11.1 potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart that coordinates the heart's beating (i.e., the hERG channel mediates the repolarizing IKr current in the cardiac action potential). When this channel's ability to conduct electrical current across the cell membrane is inhibited or compromised, either by application of drugs or by rare mutations in some families, it can result in a potentially fatal disorder called long QT syndrome; a number of clinically successful drugs in the market have had the tendency to inhibit hERG, and create a concomitant risk of sudden death, as an unwanted side effect, which has made hERG inhibition an important antitarget which must be avoided during drug development
Overview: 11.1 potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart that coordinates the heart's beating (i.e., the hERG channel mediates the repolarizing IKr current in the cardiac action potential). When this channel's ability to conduct electrical current across the cell membrane is inhibited or compromised, either by application of drugs or by rare mutations in some families, it can result in a potentially fatal disorder called long QT syndrome; a number of clinically successful drugs in the market have had the tendency to inhibit hERG, and create a concomitant risk of sudden death, as an unwanted side effect, which has made hERG inhibition an important antitarget which must be avoided during drug development
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
90,129 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily H member 2 isoform 2
NCBI Official Synonym Full Names
potassium voltage-gated channel, subfamily H (eag-related), member 2
NCBI Official Symbol
Kcnh2
NCBI Official Synonym Symbols
LQT; ERG1; Lqt2; M-erg; Merg1; merg1a; merg1b; AI326795
NCBI Protein Information
potassium voltage-gated channel subfamily H member 2
UniProt Protein Name
Potassium voltage-gated channel subfamily H member 2
Protein Family
UniProt Gene Name
Kcnh2
UniProt Synonym Gene Names
Erg; Merg1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; MERG
Uniprot Description
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) ().
Research Articles on KCNH2
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Product Notes
The Mouse KCNH2 kcnh2 (Catalog #AAA287576) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA287576 ELISA Kit recognizes Mouse KCNH2. It is sometimes possible for the material contained within the vial of "Potassium voltage-gated channel subfamily H member 2 (KCNH2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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