Rabbit ATXN2 Polyclonal Antibody | anti-ATXN2 antibody

ATXN2 Rabbit pAb

• Gene Names: ATXN2; ATX2; SCA2; ASL13; TNRC13
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity purification
• Synonyms: ATXN2; Polyclonal Antibody; ATXN2 Rabbit pAb; ATX2; SCA2; TNRC13; ataxin-2; anti-ATXN2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.05% proclin300,50% glycerol,pH7.3.

• Applicable Applications for anti-ATXN2 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: A synthetic peptide of human ATXN2
• Positive Samples: U-87MG, Mouse liver, Rat liver
• Cellular Location: Cytoplasm
• Research Area: Epigenetics & Nuclear Signaling RNA Binding
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

IF (Immunofluorescence)

(Immunofluorescence analysis of U-2 OS cells using ATXN2 antibody (AAA28401) at dilution of 1:100. Blue: DAPI for nuclear staining.)

IF (Immunofluorescence)

(Immunofluorescence analysis of L929 cells using ATXN2 antibody (AAA28401) at dilution of 1:100. Blue: DAPI for nuclear staining.)

IF (Immunofluorescence)

(Immunofluorescence analysis of C6 cells using ATXN2 antibody (AAA28401) at dilution of 1:100. Blue: DAPI for nuclear staining.)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded human colon carcinoma using ATXN2 antibody (AAA28401) at dilution of 1:100 (40x lens).)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded rat brain using ATXN2 antibody (AAA28401) at dilution of 1:100 (40x lens).)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, using ATXN2 antibody (AAA28401) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (RM00021).Exposure time: 30s.)

Related Product Information for anti-ATXN2 antibody

This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-ATXN2 antibody

Catalog Antibodies; Polyclonal Antibodies; Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 171543895
• NCBI GeneID: 6311
• NCBI Accession #: NP_002964.3
• NCBI GenBank Nucleotide #: NM_002973.3
• UniProt Accession #: Q99700; Q6ZQZ7; Q99493; A6NLD4
• Molecular Weight: 140,283 Da
• NCBI Official Full Name: ataxin-2
• NCBI Official Synonym Full Names: ataxin 2
• NCBI Official Symbol: ATXN2
• NCBI Official Synonym Symbols: ATX2; SCA2; ASL13; TNRC13
• NCBI Protein Information: ataxin-2; trinucleotide repeat containing 13; spinocerebellar ataxia type 2 protein; trinucleotide repeat-containing gene 13 protein
• UniProt Protein Name: Ataxin-2
• UniProt Gene Name: ATXN2
• UniProt Synonym Gene Names: ATX2; SCA2; TNRC13
• UniProt Entry Name: ATX2_HUMAN