Human Poly [ADP-ribose] polymerase 9 ELISA Kit | PARP9 elisa kit
Human Poly [ADP-ribose] polymerase 9 (PARP9) ELISA Kit
Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate PARP9 in Human serum, plasma. An antibody specific for PARP9 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any PARP9 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PARP9 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PARP9 bound in the initial step. The color development is stopped and the intensity of the color is measured.
NCBI and Uniprot Product Information
Uniprot Description
PARP9: Involved in inducing the expression of IFN-gamma- responsive genes. Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; EC 2.4.2.30; Motility/polarity/chemotaxis; Transferase
Chromosomal Location of Human Ortholog: 3q21.1
Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleoplasm; nucleus; protein complex
Molecular Function: enzyme binding; enzyme inhibitor activity; histone binding; NAD+ ADP-ribosyltransferase activity; protein binding
Biological Process: cell migration; double-strand break repair; negative regulation of catalytic activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; positive regulation of transcription, DNA-templated; positive regulation of tyrosine phosphorylation of STAT protein; protein ADP-ribosylation
Research Articles on PARP9
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Product Notes
The Human PARP9 parp9 (Catalog #AAA280549) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA280549 ELISA Kit recognizes Human PARP9. It is sometimes possible for the material contained within the vial of "Poly [ADP-ribose] polymerase 9, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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