TRAIL R1/DR4/TNFRSF10A Recombinant Protein | TRAILR1/DR4/TNFRSF10A recombinant protein

Recombinant Human TRAIL R1/DR4/TNFRSF10A (C-6His)

Cat. Num. AAA2569194

• Gene Names: TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: TRAIL R1/DR4/TNFRSF10A; Recombinant Human TRAIL R1/DR4/TNFRSF10A (C-6His); APO2; CD261 antigen; CD261; cytotoxic TRAIL receptor; DR4; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL-R1; TRAILR1; TRAILR1/DR4/TNFRSF10A recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Ala24-Asn239

• Species: Human
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human TRAIL R1 is produced by our Mammalian expression system and the target gene encoding Ala24-Asn239 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

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Related Product Information for TRAILR1/DR4/TNFRSF10A recombinant protein

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TNFRSF10A/DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2/TNFRSF10A is receptor for the cytotoxic ligand TNFSF10/TRAIL. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF1/TRAIL), and thus transduces cell death signal and induces cell apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF1A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

Product Categories/Family for TRAILR1/DR4/TNFRSF10A recombinant protein

Cell biology; Cardiovascular; immunology

NCBI and Uniprot Product Information

• NCBI GI #: 259906438
• NCBI GeneID: 8797
• NCBI Accession #: NP_003835.3
• NCBI GenBank Nucleotide #: NM_003844.3
• UniProt Accession #: O00220; Q53Y72; Q96E62; A8K5I4
• Molecular Weight: 50,089 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 10A
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 10a
• NCBI Official Symbol: TNFRSF10A
• NCBI Official Synonym Symbols: DR4; APO2; CD261; TRAILR1; TRAILR-1
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 10A
• UniProt Gene Name: TNFRSF10A
• UniProt Synonym Gene Names: APO2; DR4; TRAILR1; TRAIL receptor 1; TRAIL-R1
• UniProt Entry Name: TR10A_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

Uniprot Description

TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; protease binding; death receptor activity; TRAIL binding; receptor activity; transcription factor binding

Biological Process: caspase activation; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase; signal transduction