Vaccinia Virus Soluble Interferon alpha/beta Receptor B18 Recombinant Protein | VACWR200 recombinant protein
Recombinant Vaccinia Virus Soluble Interferon alpha/beta Receptor B18 Protein (C-His)
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Vaccinia Virus Soluble Interferon alpha/beta Receptor B18; Recombinant Vaccinia Virus Soluble Interferon alpha/beta Receptor B18 Protein (C-His); Soluble interferon alpha/beta receptor B18; VACWR200; VACWR200 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
Sequence
His20-Glu351
Sequence Length
351
Species
Vaccinia Virus
Endotoxin
< 1.0 EU per mug as determined by the LAL method.
Fusion Tag
C-His
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for VACWR200 recombinant protein
Protein Construction: Recombinant Vacciniavirus Soluble Interferon alpha / beta receptor B18 is produced by our mammalian expression system and the target gene encoding His20-Glu351 is expressed with a 6His tag at the C-terminus.
Background: B18R, also known as B19R in the Copenhagen strain of Vaccinia, is a type I interferon (IFN)-binding protein encoded by the B18R open reading frame in the Western Reserve strain of vaccinia virus. B18R exists in two forms, soluble and membrane-bound form and also has a broad species specificity. B18R has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. Secreted B18R binds to uninfected and infected cells. B18R presents at the cell surface and protects cells from the antiviral state. It has shown that binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.
Background: B18R, also known as B19R in the Copenhagen strain of Vaccinia, is a type I interferon (IFN)-binding protein encoded by the B18R open reading frame in the Western Reserve strain of vaccinia virus. B18R exists in two forms, soluble and membrane-bound form and also has a broad species specificity. B18R has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. Secreted B18R binds to uninfected and infected cells. B18R presents at the cell surface and protects cells from the antiviral state. It has shown that binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.
NCBI and Uniprot Product Information
NCBI GI #
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Mass: 39.2kDa
Actual Protein Molecular Mass: 50-65kDa
Actual Protein Molecular Mass: 50-65kDa
NCBI Official Full Name
IFN-alpha/beta-receptor-like secreted glycoprotein
UniProt Protein Name
Soluble interferon alpha/beta receptor B18
Protein Family
UniProt Gene Name
VACWR200
UniProt Synonym Gene Names
B18
Uniprot Description
Counteracts the antiviral effects of host IFN-alpha/beta. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
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Product Notes
The Vaccinia Virus Soluble Interferon alpha/beta Receptor B18 vacwr200 (Catalog #AAA2557619) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: His20-Glu3 51. It is sometimes possible for the material contained within the vial of "Vaccinia Virus Soluble Interferon alpha/beta Receptor B18, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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