Ferritin Light Chain Recombinant Protein | FTL recombinant protein

Recombinant Human Ferritin Light Chain Protein

Cat. Num. AAA2556632

• Gene Names: FTL; LFTD; NBIA3
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Ferritin Light Chain; Recombinant Human Ferritin Light Chain Protein; Ferritin L subunit; Ferritin light chain; FTL; FTL recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Tris, 250mM NaCl, 1mM EDTA, pH9.5.
• Sequence Length: 175

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Met1-Asp175
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for FTL recombinant protein

Protein Construction: Recombinant Human Ferritin light chain is produced by our E Coli expression system and the target gene encoding Met1-Asp175 is expressed with a 6His tag at the N-terminus.

Background: Ferritin is a large, iron-storage heteropolymeric protein,which is expressed in most kinds of cells and co-assemble in different proportion in a tissue-specific manner. Ferritin has oligomer of 24 subunits and two types of subunits including light chain(FTL) and heavy chain. Ferritin can remove Fe (II) from solution in the presence of oxygen and is very important for iron homeostasis. Iron is absorbed in the ferrous form and deposited as ferric hydroxides after oxidation. Iron is first oxidized to the ferric state for storage as ferric oxyhdroxide whithin the protein shell of ferritin. Thus, ferritin removes excess iron from the cell sap where it could otherwise participate in peroxidation mechanisms. Ferritin also plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney.

NCBI and Uniprot Product Information

• NCBI GI #: 20149498
• NCBI GeneID: 2512
• NCBI Accession #: NP_000137.2
• NCBI GenBank Nucleotide #: NM_000146.4
• UniProt Accession #: P02792; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8; B2R4B9
• Molecular Weight: Molecular Mass: 24.5kDa; Actual Protein Molecular Mass: 20-25kDa
• NCBI Official Full Name: ferritin light chain
• NCBI Official Synonym Full Names: ferritin light chain
• NCBI Official Symbol: FTL
• NCBI Official Synonym Symbols: LFTD; NBIA3
• NCBI Protein Information: ferritin light chain
• UniProt Protein Name: Ferritin light chain
• Protein Family: Ferritin
• UniProt Gene Name: FTL
• UniProt Synonym Gene Names: Ferritin L subunit

NCBI Description

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Uniprot Description

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney ().