Serine Protease Inhibitor-Clade B9 Recombinant Protein | SERPINB9 recombinant protein

Recombinant Human Serine Protease Inhibitor-Clade B9 Protein

Cat. Num. AAA2556623

• Gene Names: SERPINB9; PI9; CAP3; PI-9; CAP-3
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Serine Protease Inhibitor-Clade B9; Recombinant Human Serine Protease Inhibitor-Clade B9 Protein; Cytoplasmic antiproteinase 3; Peptidase inhibitor 9; CAP3; PI-9; Serpin B9; SERPINB9 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Length: 376

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Met1-Pro376
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for SERPINB9 recombinant protein

Protein Construction: Recombinant Human Serine Protease Inhibitor-clade B9 is produced by our Mammalian expression system and the target gene encoding Met1-Pro376 is expressed with a 6His tag at the C-terminus.

Background: Serpin B9, also known as Cytoplasmic antiproteinase 3(CAP-3), is a cytoplasm protein which belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. Serpin B9 is an inhibitor of the granzyme B/perforin lytic pathway. It is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis. Serpin-B9 expression in immune-privileged cells, APCs, and CTLs protects these cells against the actions of granzyme B, and when expressed in tumor cells or virally infected hepatocytes, confers resistance to killing by CTL and NK cells. Expression of increasing levels of Serpin-B9 in target cells may progressively inhibit immune surveillance by blocking NK and CTL-induced cytotoxicity through the perforin/granzyme pathway and then through the Fas/FasL pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 4758906
• NCBI GeneID: 5272
• NCBI Accession #: NP_004146.1
• NCBI GenBank Nucleotide #: NM_004155.6
• UniProt Accession #: P50453; Q5TD03; B2RBW3
• Molecular Weight: Molecular Mass: 43.4kDa; Actual Protein Molecular Mass: 35-40kDa
• NCBI Official Full Name: serpin B9
• NCBI Official Synonym Full Names: serpin family B member 9
• NCBI Official Symbol: SERPINB9
• NCBI Official Synonym Symbols: PI9; CAP3; PI-9; CAP-3
• NCBI Protein Information: serpin B9
• UniProt Protein Name: Serpin B9
• Protein Family: Serpin
• UniProt Gene Name: SERPINB9
• UniProt Synonym Gene Names: PI9; CAP-3; CAP3; PI-9

NCBI Description

This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

Uniprot Description

Granzyme B inhibitor.