TNF-Like 1 Recombinant Protein | TNFSF15 recombinant protein

Recombinant Human TNF-Like 1 Protein

Cat. Num. AAA2556585

• Gene Names: TNFSF15; TL1; TL1A; VEGI; TNLG1B; VEGI192A
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: TNF-Like 1; Recombinant Human TNF-Like 1 Protein; Tumor Necrosis Factor Ligand Superfamily Member 15; TNF Ligand-Related Molecule 1; Vascular Endothelial Cell Growth Inhibitor; TNFSF15; TL1; VEGI; TNFSF15 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 250mM NaCl, pH 7.5.
• Sequence Length: 192

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Met1-Leu192
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

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Related Product Information for TNFSF15 recombinant protein

Protein Construction: Recombinant Human TNF-like 1 is produced by our E Coli expression system and the target gene encoding Met1-Leu192 is expressed.

Background: Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.

NCBI and Uniprot Product Information

• NCBI GI #: 324072728
• NCBI GeneID: 9966
• NCBI Accession #: NP_001191273.1
• NCBI GenBank Nucleotide #: NM_001204344.1
• UniProt Accession #: O95150; Q3SX69; Q5VJK8; Q5VWH1; Q8NFE9
• Molecular Weight: Molecular Mass: 21.9kDa; Actual Protein Molecular Mass: 21.9kDa
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 15 isoform VEGI-192
• NCBI Official Synonym Full Names: TNF superfamily member 15
• NCBI Official Symbol: TNFSF15
• NCBI Official Synonym Symbols: TL1; TL1A; VEGI; TNLG1B; VEGI192A
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 15
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 15
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: TNFSF15
• UniProt Synonym Gene Names: TL1; VEGI

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.