Rat anti-Mouse CD127 Monoclonal Antibody | anti-CD127 antibody
Anti-Mouse CD127 Monoclonal Antibody (PE Conjugated)
Gene Names
Il7r; CD127; IL-7Ralpha
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Synonyms
CD127; Monoclonal Antibody; Anti-Mouse CD127 Monoclonal Antibody (PE Conjugated); Interleukin-7 receptor subunit alpha; Il7r; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; anti-CD127 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
A7R34
Form/Format
Liquid; PBS with 0.05% Proclin300, 1% BSA
Sequence Length
459
Applicable Applications for anti-CD127 antibody
Flow Cytometry (FC/FACS)
Conjugation
PE
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
Related Product Information for anti-CD127 antibody
CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor alpha chain or IL-7Ralpha. It forms a heterodimer with the common gamma chain (gammac or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.
References
1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125. 2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246. 3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
51,605 Da
NCBI Official Full Name
interleukin-7 receptor subunit alpha isoform 1
NCBI Official Synonym Full Names
interleukin 7 receptor
NCBI Official Symbol
Il7r
NCBI Official Synonym Symbols
CD127; IL-7Ralpha
NCBI Protein Information
interleukin-7 receptor subunit alpha
UniProt Protein Name
Interleukin-7 receptor subunit alpha
UniProt Gene Name
Il7r
UniProt Synonym Gene Names
IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA
NCBI Description
Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
Uniprot Description
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Research Articles on CD127
Similar Products
Product Notes
The CD127 il7r (Catalog #AAA2556423) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Anti-Mouse CD127 Monoclonal Antibody (PE Conjugated) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD127 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the CD127 il7r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD127, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
