Ephrin-B2/EFNB2 Recombinant Protein | EFNB2 recombinant protein

Recombinant Mouse Ephrin-B2/EFNB2 Protein (C-Fc-6His)

Cat. Num. AAA2553489

• Gene Names: Efnb2; Epl5; ELF-2; Eplg5; Htk-L; Lerk5; LERK-5; NLERK-1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Ephrin-B2/EFNB2; Recombinant Mouse Ephrin-B2/EFNB2 Protein (C-Fc-6His); Ephrin-B2; ELF-2; EPH-related receptor tyrosine kinase ligand 5; HTK ligand; Elf2; Epl5; Eplg5; Htkl; Lerk5; EFNB2 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Arg29-Glu227
• Sequence Length: 336

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: C-Fc-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for EFNB2 recombinant protein

Ephrin-B2 is a single-pass type I membrane protein and it contains 1 ephrin RBD (ephrin receptor-binding) domain. Ephrin-B2 belongs to the ephrin (EPH) family and it is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. The ephrins and EPH-related receptors contain the largest subfamily of receptor protein-tyrosine kinases and have been associated with mediating developmental events, particularly in the nervous system and in erythropoiesis. Based upon their structures and sequence relationships, ephrins are allocated into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. It also binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4 and together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration.

NCBI and Uniprot Product Information

• NCBI GI #: 31542597
• NCBI GeneID: 13642
• NCBI Accession #: NP_034241.2
• NCBI GenBank Nucleotide #: NM_010111.5
• UniProt Accession #: P52800
• Molecular Weight: Molecular Mass: 49.6 kDa; Actual Protein Molecular Mass: 63kDa
• NCBI Official Full Name: ephrin-B2
• NCBI Official Synonym Full Names: ephrin B2
• NCBI Official Symbol: Efnb2
• NCBI Official Synonym Symbols: Epl5; ELF-2; Eplg5; Htk-L; Lerk5; LERK-5; NLERK-1
• NCBI Protein Information: ephrin-B2
• UniProt Protein Name: Ephrin-B2
• Protein Family: Ephrin
• UniProt Gene Name: Efnb2
• UniProt Synonym Gene Names: Elf2; Epl5; Eplg5; Htkl; Lerk5; LERK-5; HTK-L

Uniprot Description

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.