Sterol O-Acyltransferase 2/SOAT2/ACAT2 Recombinant Protein | SOAT2/ACAT2 recombinant protein

Recombinant Human Sterol O-Acyltransferase 2/SOAT2/ACAT2 Protein (N-Trx, 6His)

Cat. Num. AAA2553256

• Gene Names: SOAT2; ACAT2; ARGP2; ACACT2
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Sterol O-Acyltransferase 2/SOAT2/ACAT2; Recombinant Human Sterol O-Acyltransferase 2/SOAT2/ACAT2 Protein (N-Trx; 6His); Acetyl-CoA acetyltransferase cytosolic; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase; ACTL; ACAT2; SOAT2/ACAT2 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Met1-Glu397
• Sequence Length: 522

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-Trx
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for SOAT2/ACAT2 recombinant protein

ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus.

NCBI and Uniprot Product Information

• NCBI GI #: 4507147
• NCBI GeneID: 8435
• NCBI Accession #: NP_003569.1
• NCBI GenBank Nucleotide #: NM_003578.3
• UniProt Accession #: O75908; Q4VB99; Q4VBA1; Q96TD4; Q9UNR2; F5H7W4; I6L9H9
• Molecular Weight: Molecular Mass: 59.1 kDa; Actual Protein Molecular Mass: 60 kDa
• NCBI Official Full Name: sterol O-acyltransferase 2
• NCBI Official Synonym Full Names: sterol O-acyltransferase 2
• NCBI Official Symbol: SOAT2
• NCBI Official Synonym Symbols: ACAT2; ARGP2; ACACT2
• NCBI Protein Information: sterol O-acyltransferase 2
• UniProt Protein Name: Sterol O-acyltransferase 2
• UniProt Gene Name: SOAT2
• UniProt Synonym Gene Names: ACACT2; ACAT2; ACAT-2

NCBI Description

Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Uniprot Description

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.