Retinoic Acid Receptor Responder Protein 2/Chemerin/TIG2 Recombinant Protein | TIG2 recombinant protein

Recombinant Human Retinoic Acid Receptor Responder Protein 2/Chemerin/TIG2 Protein (C-6His)

Cat. Num. AAA2553179

• Gene Names: RARRES2; TIG2; HP10433
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Retinoic Acid Receptor Responder Protein 2/Chemerin/TIG2; Recombinant Human Retinoic Acid Receptor Responder Protein 2/Chemerin/TIG2 Protein (C-6His); Retinoic acid receptor responder protein 2; Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein; RARRES2; TIG2; TIG2 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Glu21-Ser157
• Sequence Length: 163

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for TIG2 recombinant protein

Retinoic acid receptor responder protein 2(RARRES2) is a secreted protein that in humans is encoded by the RARRES2 gene. It is highly expressed in skin, also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon. It is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1. RARRES2 is secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. It is thought to act as a cell surface receptor, found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. RARRES2 is inhibited in psoriatic lesions, it is activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.

NCBI and Uniprot Product Information

• NCBI GI #: 4506427
• NCBI GeneID: 5919
• NCBI Accession #: NP_002880.1
• NCBI GenBank Nucleotide #: NM_002889.3
• UniProt Accession #: Q99969; Q7LE02
• Molecular Weight: Molecular Mass: 16.9 kDa; Actual Protein Molecular Mass: 14-16 kDa
• NCBI Official Full Name: retinoic acid receptor responder protein 2
• NCBI Official Synonym Full Names: retinoic acid receptor responder 2
• NCBI Official Symbol: RARRES2
• NCBI Official Synonym Symbols: TIG2; HP10433
• NCBI Protein Information: retinoic acid receptor responder protein 2
• UniProt Protein Name: Retinoic acid receptor responder protein 2
• Protein Family: Trigger factor
• UniProt Gene Name: RARRES2
• UniProt Synonym Gene Names: TIG2

NCBI Description

This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]

Uniprot Description

Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.