Melanoma Inhibitory Activity Protein/MIA Recombinant Protein | MIA recombinant protein
Recombinant Human Melanoma Inhibitory Activity Protein/MIA Protein (C-6His)
Gene Names
MIA; CD-RAP
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Melanoma Inhibitory Activity Protein/MIA; Recombinant Human Melanoma Inhibitory Activity Protein/MIA Protein (C-6His); Melanoma-Derived Growth Regulatory Protein; Melanoma Inhibitory Activity Protein; MIA; MIA recombinant protein
Host
E Coli
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Sequence Positions
Gly25-Gln131
Sequence Length
131
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fusion Tag
C-6His
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for MIA recombinant protein
Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion and promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. The protein MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas. Elevated levels of MIA may represent a clinically useful marker for identification of melanoma metastasis as well as a potential marker for rheumatoid arthritis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 13.3 kDa
Actual Protein Molecular Mass: 14 kDa
Actual Protein Molecular Mass: 14 kDa
NCBI Official Full Name
melanoma-derived growth regulatory protein
NCBI Official Synonym Full Names
MIA SH3 domain containing
NCBI Official Symbol
MIA
NCBI Official Synonym Symbols
CD-RAP
NCBI Protein Information
melanoma-derived growth regulatory protein
UniProt Protein Name
Melanoma-derived growth regulatory protein
Protein Family
UniProt Gene Name
MIA
Uniprot Description
Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
Research Articles on MIA
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Product Notes
The MIA mia (Catalog #AAA2552951) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Gly25-Gln131. It is sometimes possible for the material contained within the vial of "Melanoma Inhibitory Activity Protein/MIA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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