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Alcohol Dehydrogenase Class 4 Mu/ADH7 Recombinant Protein | ADH7 recombinant protein

Recombinant Human Alcohol Dehydrogenase Class 4 Mu/ADH7 Protein (C-6His)

Gene Names
ADH7; ADH4
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Alcohol Dehydrogenase Class 4 Mu/ADH7; Recombinant Human Alcohol Dehydrogenase Class 4 Mu/ADH7 Protein (C-6His); Alcohol Dehydrogenase Class 4 Mu/Sigma Chain; Alcohol Dehydrogenase Class IV Mu/Sigma Chain; Gastric Alcohol Dehydrogenase; Retinol Dehydrogenase; ADH7; ADH7 recombinant protein
Ordering
For Research Use Only!
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
Sequence Positions
Met1-Phe386
Sequence Length
386
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fusion Tag
C-6His
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for ADH7 recombinant protein
Alcohol dehydrogenase class 4 mu/sigma chain (ADH7) is a cytoplasm enzyme which is a member of the alcohol dehydrogenase family. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members. ADH7 may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
131
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Mass: 42.5 kDa
Actual Protein Molecular Mass: 44 kDa
NCBI Official Full Name
alcohol dehydrogenase class 4 mu/sigma chain isoform 2
NCBI Official Synonym Full Names
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
NCBI Official Symbol
ADH7
NCBI Official Synonym Symbols
ADH4
NCBI Protein Information
alcohol dehydrogenase class 4 mu/sigma chain
UniProt Protein Name
Alcohol dehydrogenase class 4 mu/sigma chain
Protein Family
UniProt Gene Name
ADH7

NCBI Description

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Description

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.MiscellaneousThere are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.CautionIt is uncertain whether Met-1 or Met-13 is the initiator.

Research Articles on ADH7

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Product Notes

The ADH7 adh7 (Catalog #AAA2552332) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Met1-Phe386. It is sometimes possible for the material contained within the vial of "Alcohol Dehydrogenase Class 4 Mu/ADH7, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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