IL13RA2 / IL13R recombinant protein
Recombinant Rat IL13RA2 / IL13R Protein (His tag)
Gene Names
Il13ra2; IL-13R-alpha-2
Purity
> 85 % as determined by SDS-PAGE
Synonyms
IL13RA2 / IL13R; Recombinant Rat IL13RA2 / IL13R Protein (His tag); IL13RA2; IL13RA2 / IL13R recombinant protein
Host
Human Cells
Purity/Purification
> 85 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
385
Application Notes
The recombinant rat IL13RA2 comprises 324 amino acids and predicts a molecular mass of 37.9 kDa. The apparent molecular mass of the recombinant protein is approximately 44 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Leu 24
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for IL13RA2 / IL13R recombinant protein
Background: Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Ralpha2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Ralpha2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Ralpha2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.
Description: A DNA sequence encoding the rat IL13RA2 (Q8VHK6) (Met1-Lys336) was expressed, fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the rat IL13RA2 (Q8VHK6) (Met1-Lys336) was expressed, fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
44,622 Da
NCBI Official Full Name
Interleukin-13 receptor subunit alpha-2
NCBI Official Synonym Full Names
interleukin 13 receptor subunit alpha 2
NCBI Official Symbol
Il13ra2
NCBI Official Synonym Symbols
IL-13R-alpha-2
NCBI Protein Information
interleukin-13 receptor subunit alpha-2
UniProt Protein Name
Interleukin-13 receptor subunit alpha-2
UniProt Gene Name
Il13ra2
UniProt Synonym Gene Names
IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2
NCBI Description
used as a target for immunotherapeutic approaches for treating brain tumors [RGD, Feb 2006]
Uniprot Description
Binds as a monomer with high affinity to interleukin-13 (IL13).
Research Articles on IL13RA2 / IL13R
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Product Notes
The IL13RA2 / IL13R il13ra2 (Catalog #AAA2547426) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat IL13RA2 comprises 324 amino acids and predicts a molecular mass of 37.9 kDa. The apparent molecular mass of the recombinant protein is approximately 44 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the IL13RA2 / IL13R il13ra2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL13RA2 / IL13R, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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