SDS-PAGE
CSF1R / MCSF Receptor / CD115 Recombinant Protein | CSF1R recombinant protein
Recombinant Rat CSF1R / MCSF Receptor / CD115 Protein (His tag)
Gene Names
Csf1r; c-fms; mrfms; CSF-1R; CSF-1-R; M-CSF-R
Purity
> 95 % as determined by SDS-PAGE
Synonyms
CSF1R / MCSF Receptor / CD115; Recombinant Rat CSF1R / MCSF Receptor / CD115 Protein (His tag); CSF1R; CSF1R recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
1022
Application Notes
The recombinant rat CSF1R comprises 502 amino acids and predicts a molecular mass of 56.5 kDa. The apparent molecular mass of the recombinant protein is approximately 69-89 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Ala 20
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CSF1R recombinant protein
Background: M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.
Description: A DNA sequence encoding the rat CSF1R (D4ACA7) (Met1-Glu510) was expressed with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the rat CSF1R (D4ACA7) (Met1-Glu510) was expressed with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
114,164 Da
NCBI Official Full Name
macrophage colony-stimulating factor 1 receptor
NCBI Official Synonym Full Names
colony stimulating factor 1 receptor
NCBI Official Symbol
Csf1r
NCBI Official Synonym Symbols
c-fms; mrfms; CSF-1R; CSF-1-R; M-CSF-R
NCBI Protein Information
macrophage colony-stimulating factor 1 receptor
UniProt Protein Name
Tyrosine-protein kinase receptor
Protein Family
UniProt Gene Name
Csf1r
NCBI Description
may mediate normal and neoplastic growth of muscular cells [RGD, Feb 2006]
Research Articles on CSF1R
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Product Notes
The CSF1R csf1r (Catalog #AAA2547283) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat CSF1R comprises 502 amino acids and predicts a molecular mass of 56.5 kDa. The apparent molecular mass of the recombinant protein is approximately 69-89 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the CSF1R csf1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CSF1R / MCSF Receptor / CD115, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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