SDS-PAGE
CD209B / DC-SIGNR1 recombinant protein
Recombinant Mouse CD209B / DC-SIGNR1 Protein (His tag)
Gene Names
Cd209b; OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
Purity
> 95 % as determined by SDS-PAGE
Synonyms
CD209B / DC-SIGNR1; Recombinant Mouse CD209B / DC-SIGNR1 Protein (His tag); 1810030I22Rik; OtB7; SIGNR1; mSIGNR1; CD209B / DC-SIGNR1 recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
325
Application Notes
The recombinant mouse CD209B comprises 268 amino acids and predicts a molecular mass of 31.4 kDa. As a result of glycosylation, the apparent molecular mass of mouse CD209B is approximately 40 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
His
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CD209B / DC-SIGNR1 recombinant protein
Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD209b, also known as SIGNR1, is a C-type lectin receptor. CD209b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD209b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD209b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.
Description: A DNA sequence encoding the extracellular domain of mouse CD209B isoform 1 (NP_081248.2) (Gln 74-Gly 325) was fused with a polyhistidine tag at the N-terminus.
Description: A DNA sequence encoding the extracellular domain of mouse CD209B isoform 1 (NP_081248.2) (Gln 74-Gly 325) was fused with a polyhistidine tag at the N-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
16,471 Da
NCBI Official Full Name
CD209 antigen-like protein B isoform a
NCBI Official Synonym Full Names
CD209b antigen
NCBI Official Symbol
Cd209b
NCBI Official Synonym Symbols
OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
NCBI Protein Information
CD209 antigen-like protein B
UniProt Protein Name
CD209 antigen-like protein B
UniProt Gene Name
Cd209b
UniProt Synonym Gene Names
DC-SIGNR1
Uniprot Description
CD209B: Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 8|8 A1.1
Cellular Component: external side of plasma membrane; integral to membrane
Molecular Function: carbohydrate binding; mannose binding; polysaccharide binding; zymosan binding
Biological Process: detection of bacterium; detection of yeast; endocytosis; phagocytosis, recognition; positive regulation of phagocytosis; positive regulation of tumor necrosis factor biosynthetic process
Research Articles on CD209B / DC-SIGNR1
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Product Notes
The CD209B / DC-SIGNR1 cd209b (Catalog #AAA2546956) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse CD209B comprises 268 amino acids and predicts a molecular mass of 31.4 kDa. As a result of glycosylation, the apparent molecular mass of mouse CD209B is approximately 40 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the CD209B / DC-SIGNR1 cd209b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD209B / DC-SIGNR1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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