SDS-PAGE
CD24 / Ly-52 / CD24A recombinant protein
Recombinant Mouse CD24 / Ly-52 / CD24A Protein (Fc tag)
Gene Names
Lyve1; Xlkd1; Lyve-1; Crsbp-1; 1200012G08Rik
Purity
> 85 % as determined by SDS-PAGE
Synonyms
CD24 / Ly-52 / CD24A; Recombinant Mouse CD24 / Ly-52 / CD24A Protein (Fc tag); CD24; Cd24a; Ly-52; CD24 / Ly-52 / CD24A recombinant protein
Host
Human Cells
Purity/Purification
> 85 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
318
Application Notes
The recombinant mouse CD24 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 267 amino acids and has a predicted molecular mass of 29.7 kDa. The apparent molecular mass of the protein is approximately 48-52 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Asn 27
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CD24 / Ly-52 / CD24A recombinant protein
Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 24, also known as signal transducer CD24 or heat stable antigen CD24 (HSA), is a mucin-type glycosylphosphatidylinositol-linked glycoprotein expressed on the surface of B-cells, differentiating neuroblasts and many tumors. It is involved in molecular adhesion and metastatic tumor spread and serve as a normal receptor for P-selectin. The CD24 / P-selectin pathway could be important in dissimenating of tumor cells by facilitating the interaction with platelet and endothelial cells. It has also been considered as a tumor marker. High rate of CD24 expressions have been found in epithelial ovarian cancer, breast cancer, non-small cell lung cancer, prostate cancer and pancreatic cancer.
Description: A DNA sequence encoding the mouse CD24 (Q8BHC0) (Met1-Arg52) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the mouse CD24 (Q8BHC0) (Met1-Arg52) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
34,574 Da
NCBI Official Full Name
lymphatic vessel endothelial hyaluronic acid receptor 1
NCBI Official Synonym Full Names
lymphatic vessel endothelial hyaluronan receptor 1
NCBI Official Symbol
Lyve1
NCBI Official Synonym Symbols
Xlkd1; Lyve-1; Crsbp-1; 1200012G08Rik
NCBI Protein Information
lymphatic vessel endothelial hyaluronic acid receptor 1
UniProt Protein Name
Lymphatic vessel endothelial hyaluronic acid receptor 1
UniProt Gene Name
Lyve1
UniProt Synonym Gene Names
Crsbp1; Xlkd1; LYVE-1; CRSBP-1
Uniprot Description
XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7|7 E3
Cellular Component: plasma membrane
Molecular Function: hyaluronic acid binding; transmembrane receptor activity
Biological Process: glycosaminoglycan catabolic process
Research Articles on CD24 / Ly-52 / CD24A
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Product Notes
The CD24 / Ly-52 / CD24A lyve1 (Catalog #AAA2546826) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse CD24 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 267 amino acids and has a predicted molecular mass of 29.7 kDa. The apparent molecular mass of the protein is approximately 48-52 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the CD24 / Ly-52 / CD24A lyve1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD24 / Ly-52 / CD24A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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