SDS-PAGE
KIM-1 / TIM1 / HAVCR1 recombinant protein
Recombinant Human KIM-1 / TIM1 / HAVCR1 Protein
Purity
> 90 % as determined by SDS-PAGE
Synonyms
KIM-1 / TIM1 / HAVCR1; Recombinant Human KIM-1 / TIM1 / HAVCR1 Protein; HAVCR; HAVCR-1; KIM-1; KIM1; TIM-1; TIM1; TIMD1; KIM-1 / TIM1 / HAVCR1 recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
Sequence Length
359
Application Notes
The secreted recombinant human KIM1 comprises 278 amino acids and predicts a molecular mass of 30 kDa. It migrates with the molecular weight in the range of 90-110 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Ser 21
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for KIM-1 / TIM1 / HAVCR1 recombinant protein
Background: Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type I integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
Description: A DNA sequence encoding the mature form of human KIM1 extracellular domain (AAC39862.1) (Ser 21-Gly 290) with a C-terminal polyhistidine tag was expressed and purified.
Description: A DNA sequence encoding the mature form of human KIM1 extracellular domain (AAC39862.1) (Ser 21-Gly 290) with a C-terminal polyhistidine tag was expressed and purified.
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
38,720 Da
NCBI Official Full Name
hepatitis A virus cellular receptor 1
UniProt Protein Name
Hepatitis A virus cellular receptor 1
UniProt Gene Name
HAVCR1
UniProt Synonym Gene Names
KIM1; TIM1; TIMD1; HAVcr-1; KIM-1; TIMD-1; TIM; TIM-1
Uniprot Description
TIM-1: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Belongs to the immunoglobulin superfamily. TIM family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q33.3
Molecular Function: viral receptor activity
Disease: Ige Responsiveness, Atopic
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Product Notes
The KIM-1 / TIM1 / HAVCR1 havcr1 (Catalog #AAA2545943) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant human KIM1 comprises 278 amino acids and predicts a molecular mass of 30 kDa. It migrates with the molecular weight in the range of 90-110 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the KIM-1 / TIM1 / HAVCR1 havcr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIM-1 / TIM1 / HAVCR1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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