Rabbit anti-Mouse DKK3  Monoclonal Antibody | anti-DKK3  antibody

Rabbit anti Mouse DKK3  Monoclonal Antibody

Cat. Num. AAA2544526

• Gene Names: DKK3; RIG; REIC
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: DKK3 ; Monoclonal Antibody; Rabbit anti Mouse DKK3 Monoclonal Antibody; anti-DKK3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 350

• Applicable Applications for anti-DKK3 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse DKK3. The detection limit for Mouse DKK3 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Mouse Dkk3 protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse DKK3 (rM DKK3; NP_056629.1; Met 1-Ile 349).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-DKK3  antibody

DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 66346689
• NCBI GeneID: 27122
• NCBI GenBank Nucleotide #: NM_001018057.1
• Molecular Weight: 38,390 Da
• NCBI Official Full Name: dickkopf-related protein 3 isoform 1
• NCBI Official Synonym Full Names: dickkopf WNT signaling pathway inhibitor 3
• NCBI Official Symbol: DKK3
• NCBI Official Synonym Symbols: RIG; REIC
• NCBI Protein Information: dickkopf-related protein 3
• UniProt Protein Name: Dickkopf-related protein 3
• UniProt Gene Name: DKK3
• UniProt Synonym Gene Names: REIC; Dickkopf-3; Dkk-3; hDkk-3
• UniProt Entry Name: DKK3_HUMAN

NCBI Description

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

DKK3: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.2

Biological Process: adrenal gland development; anatomical structure morphogenesis; negative regulation of aldosterone biosynthetic process; negative regulation of transcription, DNA-dependent