Rabbit anti-Human CLEC4A  Monoclonal Antibody | anti-CLEC4A  antibody

Rabbit anti Human CLEC4A  Monoclonal Antibody

Cat. Num. AAA2544240

• Gene Names: Clec4a; Dcir1; Clecsf6
• Reactivity: Human
• Applications: ELISA
• Synonyms: CLEC4A ; Monoclonal Antibody; Rabbit anti Human CLEC4A Monoclonal Antibody; anti-CLEC4A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 240

• Applicable Applications for anti-CLEC4A antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CLEC4A. The detection limit for Human CLEC4A is approximately 0.00245 ng/well.
• Immunogen: Recombinant Human DCIR/CLEC4A/CLECSF6 protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human DCIR/CLEC4A/CLECSF6 (rh DCIR/CLEC4A/CLECSF6; NP_001128530.1; Gln 70-Leu 237).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CLEC4A  antibody

Dendritic cell immunoreceptor (DCIR), also known as C-type lectin domain family 4 member A (CLEC4A), C-type lectin superfamily member 6 (CLECSF6), is a single-pass type II C-type lectin receptor expressed mainly in dendritic cells (DCs), which is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system. The Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle. These type II receptors contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. Additionally, DCIR can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4 (+) T cells from human immature monocyte-derived DCs. DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection.

NCBI and Uniprot Product Information

• NCBI GI #: 148235584
• NCBI GeneID: 474143
• NCBI GenBank Nucleotide #: NM_001005899.2
• Molecular Weight: 27,404 Da
• NCBI Official Full Name: C-type lectin domain family 4 member A
• NCBI Official Synonym Full Names: C-type lectin domain family 4, member A
• NCBI Official Symbol: Clec4a
• NCBI Official Synonym Symbols: Dcir1; Clecsf6
• NCBI Protein Information: C-type lectin domain family 4 member A
• UniProt Protein Name: C-type lectin domain family 4 member A
• UniProt Gene Name: Clec4a
• UniProt Synonym Gene Names: Clecsf6; Dcir
• UniProt Entry Name: CLC4A_RAT

Uniprot Description

May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation ().